About: Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages

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About: Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages
Creator	August, Avery Carter, Chavez Huang, Weishan Solouki, Sabrina Zheng, Song-Guo Deaglio, Silvia
Source	PMC
abstract	Type 1 regulatory CD4(+) T (Tr1) cells express high levels of the immunosuppressive cytokine IL-10 but not the master transcription factor Foxp3, and can suppress inflammation and promote immune tolerance. In order to identify and obtain viable Tr1 cells for research and clinical applications, co-expression of CD49b and LAG3 has been proposed as a unique surface signature for both human and mouse Tr1 cells. However, recent studies have revealed that this pattern of co-expression is dependent on the stimulating conditions and the differentiation stage of the CD4(+) T cells. Here, using an IL-10(GFP)/Foxp3(RFP) dual reporter transgenic murine model, we demonstrate that co-expression of CD49b and LAG3 is not restricted to the Foxp3(−) Tr1 cells, but is also observed in Foxp3(+) T regulatory (Treg) cells and CD8(+) T cells that produce IL-10. Our data indicate that IL-10-producing Tr1 cells, Treg cells and CD8(+) T cells are all capable of co-expressing LAG3 and CD49b in vitro following differentiation under IL-10-inducing conditions, and in vivo following pathogenic insult or infection in the pulmonary mucosa. Our findings urge caution in the use of LAG3/CD49b co-expression as sole markers to identify Tr1 cells, since it may mark IL-10-producing T cell lineages more broadly, including the Foxp3(−) Tr1 cells, Foxp3(+) Treg cells, and CD8(+) T cells.
has issue date	2018-11-19(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.02625
bibo:pmid	30510554
has license	cc-by
sha1sum (hex)	9644dba679eaf2bd1ce6c96769f5be2aff16ee40
schema:url	https://doi.org/10.3389/fimmu.2018.02625
resource representing a document's title	Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages
has PubMed Central identifier	PMC6252342
has PubMed identifier	30510554
schema:publication	Front Immunol
resource representing a document's body	covid:9644dba679eaf2bd1ce6c96769f5be2aff16ee40#body_text
is schema:about of	named entity 'CO-EXPRESSION' named entity 'Our' named entity 'T cell' named entity 'Type 1' named entity 'vivo' named entity 'Foxp3' named entity 'order' named entity 'PROPOSED' named entity 'CAUTION' named entity 'MODEL' named entity 'HIGH' named entity 'ORDER' named entity 'T CELLS' named entity 'IMMUNOSUPPRESSIVE' named entity 'OBSERVED' named entity 'DIFFERENTIATION' named entity 'SOLE' named entity 'CYTOKINE ' named entity 'CELL LINEAGES' named entity 'TO IDENTIFY' named entity 'RECENT' named entity 'T CELL' named entity 'IMMUNE TOLERANCE' named entity 'TYPE 1' named entity 'TR1' named entity 'USE OF' named entity 'PULMONARY' named entity 'CD49B' named entity 'FOR RESEARCH' named entity 'DATA' named entity 'REGULATORY' named entity 'SURFACE' named entity 'TREG' named entity 'CELLS' named entity 'GFP' named entity 'USING' named entity 'INCLUDING' named entity 'CAPABLE' named entity 'STIMULATING' named entity 'PATHOGENIC' named entity 'INDUCING' named entity 'T CELL' named entity 'PROMOTE' named entity 'APPLICATIONS' named entity 'LAG3' named entity 'IL-10' named entity 'DUAL' named entity 'INFLAMMATION' named entity 'EXPRESS' named entity 'SIGNATURE' named entity 'MOUSE' named entity 'RFP' named entity 'INSULT' named entity 'MASTER' named entity 'CD8' named entity 'MARK' named entity 'IN VITRO' named entity 'HERE' named entity 'TRANSCRIPTION FACTOR' named entity 'PRODUCING' named entity 'CELL LINEAGES' named entity 'LAG3' named entity 'PRODUCING' named entity 'CLINICAL' named entity 'BEYOND' named entity 'TYPE 1' named entity 'REGULATORY T CELLS' named entity 'STAGE' named entity 'CONDITIONS' named entity 'STUDIES' named entity 'CD4' named entity 'FOXP3' named entity 'HAVE' named entity 'HUMAN' named entity 'RESTRICTED' named entity 'MURINE'

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