About: HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion

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About: HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion
Creator	Liang, Chen Liu, Shan-Lu Wang, Yimeng Beitari, Saina
topic	covid:960f5c1ce2c58eaa9e271f8246d3844aac1082f3#this
Source	PMC
abstract	Without viral envelope proteins, viruses cannot enter cells to start infection. As the major viral proteins present on the surface of virions, viral envelope proteins are a prominent target of the host immune system in preventing and ultimately eliminating viral infection. In addition to the well-appreciated adaptive immunity that produces envelope protein-specific antibodies and T cell responses, recent studies have begun to unveil a rich layer of host innate immune mechanisms restricting viral entry. This review focuses on the exciting progress that has been made in this new direction of research, by discussing various known examples of host restriction of viral entry, and diverse viral countering strategies, in particular, the emerging role of viral envelope proteins in evading host innate immune suppression. We will also highlight the effective cooperation between innate and adaptive immunity to achieve the synergistic control of viral infection by targeting viral envelope protein and checking viral escape. Given that many of the related findings were made with HIV-1, we will use HIV-1 as the model virus to illustrate the basic principles and molecular mechanisms on host restriction targeting HIV-1 envelope protein.
has issue date	2019-03-30(xsd:dateTime)
bibo:doi	10.3390/v11040311
bibo:pmid	30935048
has license	cc-by
sha1sum (hex)	960f5c1ce2c58eaa9e271f8246d3844aac1082f3
schema:url	https://doi.org/10.3390/v11040311
resource representing a document's title	HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion
has PubMed Central identifier	PMC6521621
has PubMed identifier	30935048
schema:publication	Viruses
resource representing a document's body	covid:960f5c1ce2c58eaa9e271f8246d3844aac1082f3#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/960f5c1ce2c58eaa9e271f8246d3844aac1082f3
is schema:about of	named entity 'HIV-1' named entity 'molecular mechanisms' named entity 'principles' named entity 'host' named entity 'viral envelope proteins' named entity 'highlight' named entity 'HIV-1' named entity 'VIRIONS' named entity 'SYNERGISTIC' named entity 'RECENT' named entity 'VIRAL ENTRY' named entity 'HAVE' named entity 'IMMUNE' named entity 'PROMINENT' named entity 'ADDITION' named entity 'CELLS' named entity 'ANTIBODIES' named entity 'HOST' named entity 'RESEARCH' named entity 'CHECKING' named entity 'PRESENT' named entity 'USE' named entity 'VIRAL INFECTION' named entity 'ENVELOPE PROTEIN' named entity 'SPECIFIC' named entity 'VIRAL PROTEINS' named entity 'T CELL' named entity 'DIVERSE' named entity 'HOST' named entity 'CONTROL' named entity 'MAJOR' named entity 'VARIOUS' named entity 'KNOWN' named entity 'PREVENTING' named entity 'HIV-1' named entity 'LAYER' named entity 'ROLE' named entity 'VIRAL ENVELOPE PROTEINS' named entity 'GIVEN' named entity 'STUDIES' named entity 'IMMUNE SYSTEM' named entity 'RELATED' named entity 'ADAPTIVE IMMUNITY' named entity 'ESCAPE' named entity 'VIRUSES' named entity 'MODEL' named entity 'VIRAL ENVELOPE' named entity 'COOPERATION' named entity 'MECHANISMS' named entity 'DIRECTION' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'INFECTION' named entity 'RESTRICTION' named entity 'VIRUS' named entity 'INTERFACE' named entity 'DISCUSSING' named entity 'EFFECTIVE' named entity 'PROGRESS' named entity 'TARGET' named entity 'RICH' named entity 'STRATEGIES' named entity 'VIRUS' named entity 'PROTEIN ' named entity 'BASIC' named entity 'TARGETING' named entity 'RESTRICTION' named entity 'HIV-1' named entity 'SURFACE' named entity 'START' named entity 'FINDINGS' named entity 'ENTER' named entity 'VIRAL' named entity 'PARTICULAR' named entity 'REVIEW' named entity 'IMMUNE SUPPRESSION' named entity 'MOLECULAR'

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