About: Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus

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About: Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus
Creator	Zhang, Yi Wang, Hongning Wang, Xue Lu, Dan Guo, Zicheng Li, Yulin Yang, Tai
Source	Elsevier; Medline; PMC
abstract	Abstract The methods of repeated immunization with inactivated vaccines have been used widely to increase antibody protection against infectious bronchitis virus (IBV). However, compared with DNA vaccines, these methods usually induce poor cellular responses. In the present study, specific pathogen-free (SPF) chickens were immunized intramuscularly with a DNA vaccine carrying the main IBV structural genes (pVAX1-S1, pVAX1-M, and pVAX1-N, respectively) and boosted with the IBV M41 strain inactivated vaccine to assess whether such a new strategy could enhance the immune responses against IBV. The protection efficacy of the DNA vaccine carrying different structural genes for priming was evaluated further. The chickens were immunized primely on day 7 and boosted 2 weeks later. After that, distribution of the DNA vaccine in vivo, the percentage of CD4+CD3+ and CD8+CD3+ subgroups of peripheral blood T-lymphocytes, and the specific IgG and virus neutralizing antibodies were measured. Chickens were then challenged by the nasal–ocular route with the IBV M41 strain 4 weeks after booster immunization. The results demonstrated that priming with a DNA vaccine encoding nucleocapsid protein (pVAX1-N) and boosting with the inactivated IBV vaccine led to the dramatic augmentation of humoral and cellular responses, and provided up to 86.7% rate of immune protection, providing an effective approach to protect chickens from IBV.
has issue date	2010-07-31(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2010.03.016
bibo:pmid	20307574
has license	els-covid
sha1sum (hex)	95f96b6514c65017589e759b23d9086f48121a80
schema:url	https://doi.org/10.1016/j.jviromet.2010.03.016
resource representing a document's title	Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus
has PubMed Central identifier	PMC7112948
has PubMed identifier	20307574
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:95f96b6514c65017589e759b23d9086f48121a80#body_text
is schema:about of	named entity 'protein' named entity 'boosted' named entity 'IBV' named entity 'measured' named entity 'nucleocapsid' named entity 'responses' named entity 'CD3+' named entity 'weeks' named entity 'virus' named entity 'enhance' named entity 'IMMUNE RESPONSE' named entity 'ENCODING' named entity 'USUALLY' named entity 'DIFFERENT' named entity 'AUGMENTATION' named entity 'STRAIN' named entity 'EFFECTIVE' named entity 'DEMONSTRATED' named entity 'NEW' named entity 'VACCINE' named entity 'RESPONSES' named entity 'PROVIDED' named entity 'EVALUATED' named entity 'DAY 7' named entity 'LED' covid:arg/95f96b6514c65017589e759b23d9086f48121a80 named entity 'DNA VACCINE' named entity 'CELLULAR' named entity 'STRATEGY' named entity 'A DNA' named entity 'IMMUNIZATION' named entity 'PROTECTION EFFICACY' named entity 'NEUTRALIZING ANTIBODIES' named entity 'PRESENT' named entity 'PATHOGEN' named entity 'SPECIFIC' named entity 'THESE' named entity 'ASSESS' named entity '4 WEEKS' named entity 'IN VIVO' named entity 'APPROACH' named entity 'REPEATED' named entity 'BOOSTER IMMUNIZATION' named entity 'IGG' named entity 'RATE' named entity 'POOR' named entity 'HAVE' named entity 'RESULTS' named entity 'SUBGROUPS' named entity 'USED' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'COMPARED' named entity 'FREE' named entity 'STRUCTURAL GENES' named entity 'T-LYMPHOCYTES' named entity 'IMMUNIZED' named entity 'INDUCE' named entity 'CD4' named entity 'NASAL' named entity 'INACTIVATED' named entity 'LATER' named entity 'IMMUNE PROTECTION' named entity 'OCULAR ROUTE' named entity 'VIRUS' named entity 'M41' named entity 'ENHANCE' named entity 'PERCENTAGE' named entity 'ANTIBODY' named entity 'DNA VACCINE' named entity '2 WEEKS' named entity 'PRIMING' named entity 'BOOSTING' named entity 'MAIN' named entity 'PROVIDING'

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