About: Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients

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About: Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients
Creator	Egli, Adrian Battegay, Manuel Mikkelsen, Christina Osthoff, Michael Rauch, Andri Thiel, Steffen Trendelenburg, Marten Young, James Hirsch, Hans Jensenius, Jens Bucher, Heiner Hiv, Swiss Schä Fer, Juliane Study, Cohort
source	Medline; PMC
abstract	BACKGROUND: In HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected patients is unclear. METHODS: In a case-control study nested within the Swiss HIV Cohort Study, we investigated associations between plasma levels of MBL/ficolins and CMV disease. We compared HIV-infected patients with CMV disease (cases) to CMV-seropositive patients without CMV disease (controls) matched for CD4 T-cells, sampling time, and use of combination antiretroviral therapy. MBL and M-ficolin, L-ficolin, and H-ficolin were quantified using ELISA. RESULTS: We analysed 105 cases and 105 matched controls. CMV disease was neither associated with MBL (odds ratio [OR] 1.03 per log(10) ng/mL increase (95% CI 0.73–1.45)) nor with ficolins (OR per log(10) ng/mL increase 0.66 (95% CI 0.28–1.52), 2.34 (95% CI 0.44–12.36), and 0.89 (95% CI 0.26–3.03) for M-ficolin, L-ficolin, and H-ficolin, respectively). We found no evidence of a greater association between MBL and CMV disease in patients with low CD4 counts; however in the multivariable analysis, CMV disease was more likely in patients with an increased HIV RNA (OR 1.53 per log(10) copies/mL; 95% CI 1.08–2.16), or a shorter duration of HIV-infection (OR 0.91 per year; 95% CI 0.84–0.98). CONCLUSIONS: CMV disease is not associated with low levels of MBL/ficolins, suggesting a lack of a protective role in HIV-infected patients.
has issue date	2013-01-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0051983
bibo:pmid	23308103
has license	cc-by
sha1sum (hex)	957d77501f48dcd482bfa9491c169ffb781a3277
schema:url	https://doi.org/10.1371/journal.pone.0051983
resource representing a document's title	Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients
has PubMed Central identifier	PMC3537714
has PubMed identifier	23308103
schema:publication	PLoS One
resource representing a document's body	covid:957d77501f48dcd482bfa9491c169ffb781a3277#body_text
is schema:about of	named entity 'Cytomegalovirus' named entity 'prediction' named entity 'Lectin' named entity 'REMAINS' named entity 'CYTOMEGALOVIRUS' covid:arg/957d77501f48dcd482bfa9491c169ffb781a3277 named entity 'DISEASE' named entity 'MANNAN-BINDING LECTIN' named entity 'REPORTED' named entity 'PREDICTION' named entity 'CMV' named entity 'DIFFICULT' named entity 'UNCLEAR' named entity 'BACKGROUND' named entity 'HIV' named entity 'LOW' named entity 'HIV' named entity 'INFECTED' named entity 'DISEASE' named entity 'CYTOMEGALOVIRUS' named entity 'INCREASED RISK' named entity 'PROTECTIVE ROLE' named entity 'PATIENTS' named entity 'ASSOCIATED WITH' named entity 'LEVELS' named entity 'RISK OF' named entity 'TRANSPLANTATION' named entity 'INFECTED' named entity 'MANNAN-BINDING LECTIN' named entity 'IMPACT' named entity 'BUT' named entity 'PATIENTS' named entity 'CMV' named entity 'HIV-infected patients' named entity 'mannan-binding lectin' named entity 'HIV-infected patients' named entity 'Cytomegalovirus' named entity 'Ficolins' named entity 'MBL' named entity 'general population' named entity 'ionic strength' named entity 'CMV disease' named entity 'achieve control' named entity 'MBL' named entity 'MBL deficiency' named entity 'glycoproteins' named entity 'MBL' named entity 'ficolin' named entity 'CD4 T-cell' named entity 'CMV disease' named entity 'MBL deficiency' named entity 'transplant recipients' named entity 'acute phase' named entity 'HIV' named entity 'PCR' named entity 'atrophy' named entity 'MBL' named entity 'diagnostic accuracy' named entity 'lymph nodes' named entity 'kidney' named entity 'index case' named entity 'positive test' named entity 'severe acute respiratory syndrome coronavirus' named entity 'HIV' named entity 'immunosuppression' named entity 'complement-mediated' named entity 'dengue virus' named entity 'RNA'

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