About: Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection

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About: Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection
Creator	Fernandez-Sesma, Ana Maringer, Kevin
Source	Elsevier; Medline; PMC
abstract	STING has emerged in recent years as an important signalling adaptor in the activation of type I interferon responses during infection with DNA viruses and bacteria. An increasing body of evidence suggests that STING also modulates responses to RNA viruses, though the mechanisms remain less clear. In this review, we give a brief overview of the ways in which STING facilitates sensing of RNA viruses. These include modulation of RIG-I-dependent responses through STING's interaction with MAVS, and more speculative mechanisms involving the DNA sensor cGAS and sensing of membrane remodelling events. We then provide an in-depth literature review to summarise the known mechanisms by which RNA viruses of the families Flaviviridae and Coronaviridae evade sensing through STING. Our own work has shown that the NS2B/3 protease complex of the flavivirus dengue virus binds and cleaves STING, and that an inability to degrade murine STING may contribute to host restriction in this virus. We contrast this to the mechanism employed by the distantly related hepacivirus hepatitis C virus, in which STING is bound and inactivated by the NS4B protein. Finally, we discuss STING antagonism in the coronaviruses SARS coronavirus and human coronavirus NL63, which disrupt K63-linked polyubiquitination and dimerisation of STING (both of which are required for STING-mediated activation of IRF-3) via their papain-like proteases. We draw parallels with less-well characterised mechanisms of STING antagonism in related viruses, and place our current knowledge in the context of species tropism restrictions that potentially affect the emergence of new human pathogens.
has issue date	2014-12-01(xsd:dateTime)
bibo:doi	10.1016/j.cytogfr.2014.08.004
bibo:pmid	25212897
has license	cc-by-nc-sa
sha1sum (hex)	95742e15e5dc39ed30e4b72398dd4a49507dcec1
schema:url	https://doi.org/10.1016/j.cytogfr.2014.08.004
resource representing a document's title	Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection
has PubMed Central identifier	PMC4330990
has PubMed identifier	25212897
schema:publication	Cytokine Growth Factor Rev
resource representing a document's body	covid:95742e15e5dc39ed30e4b72398dd4a49507dcec1#body_text
is schema:about of	named entity 'MINI' named entity 'STING' named entity 'Message' named entity 'LEARNED' named entity 'VIRUS INFECTION' named entity 'BOTTLE' named entity 'RNA VIRUS' named entity 'SIGNALLING' named entity 'REVIEW' named entity 'STING' named entity 'MESSAGE' named entity 'ANTAGONISM' named entity 'infection' named entity 'STING' named entity 'Message in a bottle' named entity 'coronaviruses' named entity 'SeV' named entity 'YFV' named entity 'transmembrane domain' named entity 'clinical testing' named entity 'target site' named entity 'type I IFN' named entity 'polyprotein' named entity 'knock-out mice' named entity 'STING' named entity 'phosphorylation' named entity 'SFV' named entity 'fluorescent protein' named entity 'type I IFN' named entity 'alphacoronavirus' named entity 'phosphorylation' named entity 'IRF-3' named entity 'N-terminus' named entity 'IFN' named entity 'vector' named entity 'interact' named entity 'cGAS' named entity 'TBK1' named entity 'STING' named entity 'viral entry' named entity 'bone marrow' named entity 'STING' named entity 'signalling molecule' named entity 'deubiquitinase' named entity 'phosphorylation' named entity 'DENV' named entity 'evolutionary conservation' named entity 'hepatitis virus' named entity 'RNA viruses' named entity 'viruses' named entity 'JEV' named entity 'zoonotic pathogens' named entity 'cleavage' named entity 'STING' named entity 'Flaviviridae' named entity 'protease' named entity 'STING' named entity 'nuclear translocation' named entity 'DENV' named entity 'infection' named entity 'antiviral' named entity 'PLP2' named entity 'protease' named entity 'endogenous' named entity 'luciferase' named entity 'hepatocellular carcinoma' named entity 'vaccine' named entity 'YFV' named entity 'NS4B' named entity 'coronaviruses' named entity '293T' named entity 'cytoplasm' named entity 'TBK1' named entity 'TBK1' named entity 'dendritic cells' named entity 'infection' named entity 'RNA virus' named entity 'SARS-CoV' named entity 'endogenous' named entity 'type I IFN'

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