About: Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion
Creator	Licona-Limón, Ileana Ortega, Enrique Garay-Canales, Claudia
Source	Medline; PMC
abstract	CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metastasis. CD13 has also been proposed to participate in cell adhesion, as crosslinking of CD13 by certain CD13-specific antibodies induces homotypic aggregation of monocytes and heterotypic adhesion of monocytes to endothelial cells. We generated two monoclonal antibodies (mAbs C and E) that block homotypic aggregation of U-937 monocytic cells induced by CD13-specific mAb 452. Moreover, the mAbs cause detachment of cells whose aggregation was induced by CD13 crosslinking. Both mAbs also inhibit heterotypic adhesion of U-937 monocytes to endothelial cells. mAbs C and E recognize membrane CD13 but bind to epitopes different from that recognized by mAb 452. Crosslinking of CD13 by mAb C or E is required to inhibit adhesion, as monovalent Fab fragments are not sufficient. Thus, C and E antibodies recognize a distinct epitope on CD13, and binding to this epitope interferes with both CD13-mediated cell adhesion and enzymatic activity. These antibodies may represent important tools to study cell-cell interactions mediated by CD13 in physiological and pathological conditions.
has issue date	2018-03-29(xsd:dateTime)
bibo:doi	10.1155/2018/4093435
bibo:pmid	29789790
has license	cc-by
sha1sum (hex)	95375dac99b10d7628f9c154db3799825c2f101f
schema:url	https://doi.org/10.1155/2018/4093435
resource representing a document's title	Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion
has PubMed Central identifier	PMC5896358
has PubMed identifier	29789790
schema:publication	Biomed Res Int
resource representing a document's body	covid:95375dac99b10d7628f9c154db3799825c2f101f#body_text
is schema:about of	named entity 'crosslinking' named entity 'inhibit' named entity 'aggregation' named entity 'participates' named entity 'interferes' named entity 'monocytes' named entity 'Mediate' covid:arg/95375dac99b10d7628f9c154db3799825c2f101f named entity 'bioactive' named entity 'peptides' named entity 'epitope' named entity 'monocytes' named entity 'induces' named entity 'binding' named entity 'neutrophils' named entity 'enzymatic activity' named entity 'Fab' named entity 'conditions' named entity 'recognize' named entity 'aminopeptidase' named entity 'cell adhesion' named entity 'monocytic' named entity 'membrane' named entity 'generated' named entity 'Adhesion' named entity 'receptor' named entity 'CD13' named entity 'membrane glycoprotein' named entity 'angiogenesis' named entity 'monocytes' named entity 'mAbs' named entity 'myeloid cells' named entity 'monovalent' named entity 'CD13' named entity 'Mediate' named entity 'Epitopes' named entity 'CD13' named entity 'specific' named entity 'macrophages' named entity 'monocytic' named entity 'hybridomas' named entity 'phosphotyrosine' named entity 'CD13' named entity 'precipitate' named entity 'fibronectin' named entity 'motif' named entity 'THP-1' named entity 'fibronectin' named entity 'precleared' named entity 'Salts' named entity 'mAb' named entity 'CD13' named entity 'mAbs' named entity 'signal transduction' named entity 'BSA' named entity 'monocyte' named entity 'tyrosine' named entity 'catalytic site' named entity 'HEK-293' named entity 'mAb' named entity 'monoclonal antibodies' named entity 'oligopeptides' named entity 'Immunoprecipitates' named entity 'endothelial cells' named entity 'conformation' named entity 'CD13' named entity 'CD13' named entity 'mAb' named entity 'physiological' named entity 'mAb' named entity 'signal transduction' named entity 'pharmacological' named entity 'glycosylated' named entity 'fibronectin' named entity 'CD13' named entity 'CD13' named entity 'mAb' named entity 'mAbs' named entity 'protease'

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