About: Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review
Creator	Cripps, Allan Massa, Helen Ngo, Chinh Thornton, Ruth
source	Medline; PMC
abstract	BACKGROUND: Otitis media (OM) is amongst the most common childhood diseases and is associated with multiple microbial pathogens within the middle ear. Global and temporal monitoring of predominant bacterial pathogens is important to inform new treatment strategies, vaccine development and to monitor the impact of vaccine implementation to improve progress toward global OM prevention. METHODS: A systematic review of published reports of microbiology of acute otitis media (AOM) and otitis media with effusion (OME) from January, 1970 to August 2014, was performed using PubMed databases. RESULTS: This review confirmed that Streptococcus pneumoniae and Haemophilus influenzae, remain the predominant bacterial pathogens, with S. pneumoniae the predominant bacterium in the majority reports from AOM patients. In contrast, H. influenzae was the predominant bacterium for patients experiencing chronic OME, recurrent AOM and AOM with treatment failure. This result was consistent, even where improved detection sensitivity from the use of polymerase chain reaction (PCR) rather than bacterial culture was conducted. On average, PCR analyses increased the frequency of detection of S. pneumoniae and H. influenzae 3.2 fold compared to culture, whilst Moraxella catarrhalis was 4.5 times more frequently identified by PCR. Molecular methods can also improve monitoring of regional changes in the serotypes and identification frequency of S. pneumoniae and H. influenzae over time or after vaccine implementation, such as after introduction of the 7-valent pneumococcal conjugate vaccine. CONCLUSIONS: Globally, S. pneumoniae and H. influenzae remain the predominant otopathogens associated with OM as identified through bacterial culture; however, molecular methods continue to improve the frequency and accuracy of detection of individual serotypes. Ongoing monitoring with appropriate detection methods for OM pathogens can support development of improved vaccines to provide protection from the complex combination of otopathogens within the middle ear, ultimately aiming to reduce the risk of chronic and recurrent OM in vulnerable populations.
has issue date	2016-03-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0150949
bibo:pmid	26953891
has license	cc-by
sha1sum (hex)	94fc08607ba07e9f5a0239d27251d4cdcc6bfd9a
schema:url	https://doi.org/10.1371/journal.pone.0150949
resource representing a document's title	Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review
has PubMed Central identifier	PMC4783106
has PubMed identifier	26953891
schema:publication	PLoS One
resource representing a document's body	covid:94fc08607ba07e9f5a0239d27251d4cdcc6bfd9a#body_text
is schema:about of	named entity 'CHILDREN' named entity 'TEMPORAL' named entity 'MICROBIAL PATHOGENS' named entity 'MONITOR' named entity 'ASSOCIATED WITH' named entity 'TREATMENT' named entity 'IMPORTANT' named entity 'OTITIS MEDIA' named entity 'CHILDHOOD DISEASES' named entity 'MULTIPLE' named entity 'MIDDLE EAR FLUID' named entity 'SYSTEMATIC REVIEW' named entity 'TO INFORM' named entity 'VACCINE DEVELOPMENT' named entity 'OTITIS MEDIA' named entity 'BACTERIAL PATHOGENS' named entity 'PREDOMINANT' named entity 'DETECTED' named entity 'PREVENTION' named entity 'COMMON' named entity 'MIDDLE EAR' named entity 'GLOBAL' named entity 'BACTERIA ' named entity 'IMPACT' named entity 'NEW' named entity 'VACCINE' named entity 'PREDOMINANT' named entity 'IMPLEMENTATION' named entity 'MONITORING' named entity 'PROGRESS' named entity 'STRATEGIES' covid:arg/94fc08607ba07e9f5a0239d27251d4cdcc6bfd9a named entity 'microbial' named entity 'Systematic Review' named entity 'Otitis Media' named entity 'fever' named entity 'pneumococcal' named entity 'Australia' named entity 'H. influenzae' named entity 'S. pneumoniae' named entity 'S. pneumoniae' named entity 'H. influenzae' named entity 'S. pneumoniae' named entity '10/17' named entity 'clinical presentation' named entity 'PCR' named entity 'bacteria' named entity 'Africa' named entity 'bacteria' named entity 'β-lactamase' named entity 'perforation' named entity 'serotypes' named entity 'S. pyogenes' named entity 'H. influenzae' named entity 'otitis media' named entity 'pathogenesis' named entity 'H. influenzae' named entity 'serotypes' named entity 'inflammatory' named entity 'Singapore' named entity '3.2%' named entity 'Oceania' named entity 'Costa Rica' named entity 'S. pneumoniae' named entity 'Asia' named entity 'Americas' named entity 'Pseudomonas' named entity 'Brunei' named entity 'United States' named entity 'S. pneumoniae' named entity 'viruses' named entity 'M. catarrhalis' named entity 'Mexico' named entity 'serotypes' named entity 'S. pneumoniae' named entity 'bacteria' named entity 'NTHi' named entity 'respiratory syncytial virus'

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