About: The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?

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About: The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?
Creator	Bastarrachea, Raul Cole, Shelley Laviada-Molina, Hugo Rodriguez-Ayala, Ernesto Serres-Perales, Jeannette
Source	Medline; PMC
abstract	An altered immune response to pathogens has been suggested to explain increased susceptibility to infectious diseases in patients with diabetes. Recent evidence has documented several immunometabolic pathways in patients with diabetes directly related to the COVID-19 infection. This also seems to be the case for prediabetic subjects with proinflammatory insulin resistance syndrome accompanied with prothrombotic hyperinsulinemic and dysglycemic states. Patients with frank hyperglycemia, dysglycemia and/or hyperinsulinemia develop systemic immunometabolic inflammation with higher levels of circulating cytokines. This deleterious scenario has been proposed as the underlying mechanism enhancing a cytokine storm-like hyperinflammatory state in diabetics infected with severe COVID-19 triggering multi-organ failure. Compared with moderately affected COVID-19 patients, diabetes was found to be highly prevalent among severely affected patients suggesting that this non-communicable disease should be considered as a risk factor for adverse outcomes. The COVID-19 pandemic mirrors with the diabetes pandemic in many pathobiological aspects. Our interest is to emphasize the ties between the immunoinflammatory mechanisms that underlie the morbidity and lethality when COVID-19 meets diabetes. This review brings attention to two pathologies of highly complex, multifactorial, developmental and environmentally dependent manifestations of critical importance to human survival. Extreme caution should be taken with diabetics with suspected symptoms of COVID-19 infection.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.3390/pathogens9050389
bibo:pmid	32438687
has license	cc-by
sha1sum (hex)	94d1ad385095a77408e306910b25ee7240dd6d8b
schema:url	https://doi.org/10.3390/pathogens9050389
resource representing a document's title	The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?
has PubMed Central identifier	PMC7281197
has PubMed identifier	32438687
schema:publication	Pathogens
resource representing a document's body	covid:94d1ad385095a77408e306910b25ee7240dd6d8b#body_text
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