About: An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections

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About: An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections
Creator	Wan, Cho-Hua Chueh, Ling-Ling Wang, Ying-Ting
Source	Medline; PMC
abstract	BACKGROUND: Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV). FCoVs are divided into two serotypes with markedly different infection rates among cat populations around the world. A baculovirus-expressed type-specific domain of the spike proteins of FCoV was used to survey the infection of the two viruses over the past eight years in Taiwan. RESULTS: An immunofluorescence assay based on cells infected with the recombinant viruses that was capable of distinguishing between the two types of viral infection was established. A total of 833 cases from a teaching hospital was surveyed for prevalence of different FCoV infections. Infection of the type I FCoV was dominant, with a seropositive rate of 70.4%, whereas 3.5% of cats were infected with the type II FCoV. In most cases, results derived from serotyping and genotyping were highly agreeable. However, 16.7% (4/24) FIP cats and 9.8% (6/61) clinically healthy cats were found to possess antibodies against both viruses. Moreover, most of the cats (84.6%, 22/26) infected with a genotypic untypable virus bearing a type I FCoV antibody. CONCLUSION: A relatively simple serotyping method to distinguish between two types of FCoV infection was developed. Based on this method, two types of FCoV infection in Taiwan was first carried out. Type I FCoV was found to be predominant compared with type II virus. Results derived from serotyping and genotyping support our current understanding of evolution of disease-related FCoV and transmission of FIP.
has issue date	2014-08-15(xsd:dateTime)
bibo:doi	10.1186/s12917-014-0186-7
bibo:pmid	25123112
has license	cc-by
sha1sum (hex)	94c6aacd8aeb83b9798d43627bcf867944fb8afd
schema:url	https://doi.org/10.1186/s12917-014-0186-7
resource representing a document's title	An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections
has PubMed Central identifier	PMC4236817
has PubMed identifier	25123112
schema:publication	BMC Vet Res
resource representing a document's body	covid:94c6aacd8aeb83b9798d43627bcf867944fb8afd#body_text
is schema:about of	named entity 'PROTEINS' named entity 'Infection' named entity 'disease' named entity 'populations' named entity 'cats' named entity 'cells' named entity 'CORONAVIRUS INFECTIONS' named entity 'FELINE CORONAVIRUS' named entity 'ANTIBODY' named entity 'TYPES' named entity 'YEAR' named entity 'TOTAL' named entity 'POSSESS' named entity '3.5' named entity 'SPIKE' named entity 'RECOMBINANT' named entity 'FATAL DISEASE' named entity 'TYPE' named entity 'EXPRESSED' named entity 'IS A' named entity 'BEARING' named entity 'RESULTS' named entity 'CAT' named entity 'CAPABLE' named entity 'GENOTYPIC' named entity '833' named entity 'CAUSED BY' named entity 'BASED' named entity 'BACKGROUND' named entity 'FOUND' named entity 'ESTABLISHED' named entity 'DISTINGUISHING' named entity 'VIRUS' named entity 'DIFFERENTIATION' named entity 'SPECIFIC' named entity 'EXPRESSED' named entity 'BACULOVIRUS' named entity 'TYPE' named entity 'DOMAIN' named entity 'SPECIFIC' named entity 'RATE' named entity 'USED' named entity 'CATS' named entity 'TAIWAN' named entity 'CELLS' named entity 'PREVALENCE' named entity 'UNTYPABLE' named entity 'DOMINANT' named entity '16.7' named entity '2884' named entity 'ANTIBODIES' named entity 'SEROTYPES' named entity 'VIRUSES' named entity 'TYPE II' named entity 'SEROTYPING' named entity 'INFECTION' named entity 'SEROPOSITIVE' named entity 'INFECTED' named entity 'MOST OF' named entity 'VIRAL INFECTION' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'BASED' named entity 'HEALTHY' named entity 'PROTEINS' named entity 'FELINE CORONAVIRUS' named entity 'MARKEDLY' named entity 'YEARS' named entity 'WORLD' named entity 'TEACHING HOSPITAL' named entity 'GENOTYPING' named entity 'DERIVED' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'SPIKE' named entity 'SURVEY' named entity 'RATES' named entity 'CASES' named entity 'DIVIDED' named entity 'TYPE I' named entity 'HIGHLY'

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