About: Mapping genetic determinants of viral traits with F ST and quantitative trait locus (QTL) approaches

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About: Mapping genetic determinants of viral traits with F ST and quantitative trait locus (QTL) approaches Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mapping genetic determinants of viral traits with F ST and quantitative trait locus (QTL) approaches
Creator	Peterschmitt, Michel Thébaud, Gaël Urbino, Cica Vuillaume, Florence Doumayrou, Juliette
Source	Elsevier; Medline; PMC
abstract	Abstract The genetic determinism of viral traits can generally be dissected using either forward or reverse genetics because the clonal reproduction of viruses does not require the use of approaches based on laboratory crosses. Nevertheless, we hypothesized that recombinant viruses could be analyzed as sexually reproducing organisms, using either a quantitative trait loci (QTL) approach or a locus-by-locus fixation index (F ST). Locus-by-locus F ST analysis, and four different regressions and interval mapping algorithms of QTL analysis were applied to a phenotypic and genotypic dataset previously obtained from 47 artificial recombinant genomes generated between two begomovirus species. Both approaches assigned the determinant of within-host accumulation—previously identified using standard virology approaches—to a region including the 5׳ end of the replication-associated protein (Rep) gene and the upstream intergenic region. This study provides a proof of principle that QTL and population genetics tools can be extended to characterize the genetic determinants of viral traits.
has issue date	2015-10-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.06.019
bibo:pmid	26186573
has license	els-covid
sha1sum (hex)	94838a002448763b9e8c01f786e25825e351280a
schema:url	https://doi.org/10.1016/j.virol.2015.06.019
resource representing a document's title	Mapping genetic determinants of viral traits with F ST and quantitative trait locus (QTL) approaches
has PubMed Central identifier	PMC7111638
has PubMed identifier	26186573
schema:publication	Virology
resource representing a document's body	covid:94838a002448763b9e8c01f786e25825e351280a#body_text
is schema:about of	named entity 'organisms' named entity 'This' named entity 'clonal' named entity 'population genetics' named entity 'region' named entity 'genotypic' named entity 'ANALYZED' covid:arg/94838a002448763b9e8c01f786e25825e351280a named entity 'REPLICATION' named entity 'MAPPING ALGORITHMS' named entity 'OBTAINED' named entity 'APPROACHES' named entity 'PROVIDES' named entity 'SEXUALLY' named entity 'SPECIES' named entity 'GENERALLY' named entity 'USE OF' named entity 'DATASET' named entity 'REGION' named entity 'TRAITS' named entity 'QUANTITATIVE TRAIT LOCUS' named entity 'INCLUDING' named entity 'VIROLOGY' named entity 'DIFFERENT' named entity 'BASED' named entity 'ACCUMULATION' named entity 'VIRAL' named entity 'DETERMINANTS' named entity 'GENETIC' named entity 'QUANTITATIVE TRAIT LOCI' named entity 'DETERMINANT' named entity 'INTERGENIC REGION' named entity 'EITHER' named entity 'HOST' named entity 'APPROACHES' named entity 'VIRAL' named entity 'MAPPING' named entity 'GENETIC' named entity 'CROSSES' named entity 'DETERMINANTS' named entity 'GENOTYPIC' named entity 'ORGANISMS' named entity 'INTERVAL' named entity 'BEGOMOVIRUS' named entity 'VIRUSES' named entity 'GENERATED' named entity 'APPROACH' named entity 'PROOF' named entity 'QTL ANALYSIS' named entity 'TOOLS' named entity 'REPRODUCING' named entity 'LABORATORY' named entity 'GENETIC DETERMINISM' named entity 'ASSIGNED' named entity 'TO CHARACTERIZE' named entity 'PROTEIN ' named entity 'PREVIOUSLY' named entity 'STANDARD' named entity 'ARTIFICIAL' named entity 'QTL' named entity 'DOES NOT' named entity 'GENOMES' named entity 'ASSOCIATED' named entity 'POPULATION GENETICS' named entity 'DISSECTED' named entity 'REGRESSIONS' named entity 'EXTENDED' named entity 'UPSTREAM' named entity 'APPLIED' named entity 'PRINCIPLE' named entity 'COULD BE' named entity 'FORWARD' named entity 'ANALYSIS' named entity 'FIXATION' named entity 'TRAITS' named entity 'CLONAL REPRODUCTION' named entity 'LOCUS'

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