About: A comparative study of experimental mouse models of central nervous system demyelination

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A comparative study of experimental mouse models of central nervous system demyelination
Creator	Ghiasi, Homayon Dumitrascu, Oana Mott, Kevin
Source	PMC
abstract	Several mouse models of multiple sclerosis (MS) are now available. We have established a mouse model, in which ocular infection with a recombinant HSV-1 that expresses murine IL-2 constitutively (HSV-IL-2) causes CNS demyelination in different strains of mice. This model differs from most other models in that it represents a mixture of viral and immune triggers. In the present study, we directly compared MOG(35–55), MBP(35–47), and PLP(190–209) models of EAE with our HSV-IL-2-induced MS model. Mice with HSV-IL-2-induced and MOG-induced demyelinating diseases demonstrated a similar pattern and distribution of demyelination in their brain, spinal cord, and optic nerves. In contrast, no demyelination was detected in the optic nerves of MBP- and PLP-injected mice. IFN-β injections significantly reduced demyelination in brains of all groups, in the spinal cords of the MOG and MBP groups, and completely blocked it in the spinal cords of the PLP and HSV-IL-2 groups as well as in optic nerves of MOG and HSV-IL-2 groups. In contrast to IFN-β treatment, IL-12p70 protected the HSV-IL-2 group from demyelination, while IL-4 was not effective at all in preventing demyelination. MOG-injected mice showed clinical signs of paralysis and disease-related mortality whereas mice in the other treatment groups did not. Collectively, the results indicate that the HSV-IL-2 model and the MOG model complement each other and, together, provide unique insights into the heterogeneity of human MS.
has issue date	2014-04-10(xsd:dateTime)
bibo:doi	10.1038/gt.2014.33
bibo:pmid	24718267
has license	no-cc
sha1sum (hex)	943576d41ee9cd2a8be3379fa2ff1bc8963a3202
schema:url	https://doi.org/10.1038/gt.2014.33
resource representing a document's title	A comparative study of experimental mouse models of central nervous system demyelination
has PubMed Central identifier	PMC4047154
has PubMed identifier	24718267
schema:publication	Gene Ther
resource representing a document's body	covid:943576d41ee9cd2a8be3379fa2ff1bc8963a3202#body_text
is schema:about of	named entity 'demyelination' named entity 'optic nerves' named entity 'brains' named entity '[39' named entity 'PUBLIC' named entity 'MOUSE MODELS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'CONTRAST' named entity 'INJECTIONS' named entity 'AVAILABLE' named entity 'PROVIDE' named entity 'TRIGGERS' named entity 'RESULTS' named entity 'SIMILAR' named entity 'REDUCED' named entity 'VIRAL AND' named entity 'TREATMENT' named entity 'MOUSE MODEL' named entity 'PRESENT' named entity 'COMPLETELY' named entity 'OTHER TREATMENT' named entity 'BRAIN' named entity 'RECOMBINANT' named entity 'OPTIC NERVES' named entity 'CAUSES' named entity 'DEMONSTRATED' named entity 'HUMAN' named entity 'HETEROGENEITY' named entity 'MOUSE MODELS' named entity 'THEIR' named entity 'PATTERN' named entity 'ESTABLISHED' named entity 'HSV-1' named entity 'STUDY' named entity 'PARALYSIS' named entity 'MULTIPLE SCLEROSIS' named entity 'EAE' named entity 'DETECTED' named entity 'RELATED' named entity 'OUR' named entity 'OCULAR INFECTION' named entity 'MS.' named entity 'STRAINS' named entity 'IFN' named entity 'DISTRIBUTION' named entity 'MICE' named entity 'SPINAL CORD' named entity 'EXPERIMENTAL' named entity 'HHS' named entity 'COMPARED' named entity 'COMPLEMENT' named entity 'GROUP' named entity 'DEMYELINATING DISEASES' named entity 'MIXTURE' named entity 'INSIGHTS' named entity 'AUTHOR' named entity 'MODEL' named entity 'DIFFERENT' named entity 'MURINE' named entity 'EFFECTIVE' named entity 'ACCESS' named entity 'MANUSCRIPT' named entity 'COMPARATIVE STUDY' named entity 'DEMYELINATION' named entity 'BLOCKED' named entity 'IL-2' named entity 'MORTALITY' named entity 'DISEASE' named entity 'MOG' named entity 'MBP' named entity 'MODELS' named entity 'DID' named entity 'DEMYELINATION' named entity 'PREVENTING' named entity 'CNS DEMYELINATION' named entity 'PLP' named entity 'DIRECTLY' named entity 'GROUPS' named entity 'UNIQUE'

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