About: Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD

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About: Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD
Creator	Zhu, Jie Footitt, Joseph Mallia, Patrick Johnston, Sebastian Contoli, Marco Papi, Alberto Aniscenko, Julia Kebadze, Tatiana Adcock, Ian Barnes, Peter Message, Simon Contoli, Johnson Im, Adcock Jeffery, Peter Johnson, Malcolm Kon, Onn La, Stanciu Om, Kon Pj, Barnes Pk, Jeffery Qiu, Yusheng Stanciu, Luminita
Source	Elsevier; Medline; PMC
abstract	Abstract Background Respiratory viral infection causes chronic obstructive pulmonary disease (COPD) exacerbations. We previously reported increased bronchial mucosa eosinophil and neutrophil inflammation in COPD experiencing naturally occurring exacerbations. But it is unclear whether virus per se induces bronchial mucosal inflammation, nor whether this relates to exacerbation severity. Objectives To determine the extent and nature of bronchial mucosal inflammation following experimental rhinovirus (RV)-16-induced COPD exacerbations and its relationship to disease severity. Methods Bronchial mucosal inflammatory cell phenotypes were determined at pre-infection baseline and following experimental RV infection in 17 GOLD stage II COPD subjects and as controls, 20 smokers and 11 non-smokers, with normal lung function. No subject had a history of asthma/allergic rhinitis: all were negative for aero-allergen skin prick tests. Results RV-infection increased the numbers of bronchial mucosal eosinophils and neutrophils only in COPD and CD8+ T-lymphocytes in COPD and non-smokers. Monocytes/macrophages, CD4+ T- and CD20+ B-lymphocytes were increased in all subjects. At baseline, compared to non-smokers, COPD subjects and smokers had increased numbers of bronchial mucosal monocytes/macrophages and CD8+ T-lymphocytes but fewer numbers of CD4+ T- and CD20+ B-lymphocytes. The virus-induced inflammatory cells in COPD were positively associated with virus load, illness severity and reductions in lung function. Conclusion Experimental rhinovirus infection induces bronchial mucosal eosinophilia and neutrophilia only in COPD and monocytes/macrophages and lymphocytes in both COPD and control subjects. The virus-induced inflammatory cell phenotypes observed in COPD positively related to virus load, illness severity. Anti-viral/anti-inflammatory therapies could attenuate bronchial inflammation and ameliorate virus-induced COPD exacerbations.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2020.03.021
bibo:pmid	32283204
has license	els-covid
sha1sum (hex)	9371a394c51f936cba04f0661a9f0b02e4c2a911
schema:url	https://doi.org/10.1016/j.jaci.2020.03.021
resource representing a document's title	Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD
has PubMed Central identifier	PMC7173046
has PubMed identifier	32283204
schema:publication	The Journal of allergy and clinical immunology
resource representing a document's body	covid:9371a394c51f936cba04f0661a9f0b02e4c2a911#body_text
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