About: Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge
Creator	Feldmann, Heinz Safronetz, David Scott, Dana Zivcec, Marko Robertson, Shelly
Source	PMC
abstract	Crimean-Congo hemorrhagic fever (CCHF) is an acute, often fatal viral disease characterized by rapid onset of febrile symptoms followed by hemorrhagic manifestations. The etiologic agent, CCHF orthonairovirus (CCHFV), can infect several mammals in nature but only seems to cause clinical disease in humans. Over the past two decades there has been an increase in total number of CCHF case reports, including imported CCHF patients, and an expansion of CCHF endemic areas. Despite its increased public health burden there are currently no licensed vaccines or treatments to prevent CCHF. We here report the development and assessment of the protective efficacy of an adenovirus (Ad)-based vaccine expressing the nucleocapsid protein (N) of CCHFV (Ad-N) in a lethal immunocompromised mouse model of CCHF. The results show that Ad-N can protect mice from CCHF mortality and that this platform should be considered for future CCHFV vaccine strategies.
has issue date	2018-07-16(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0006628
bibo:pmid	30011277
has license	cc0
sha1sum (hex)	936e6e20342454e2646bd840d70148c893262146
schema:url	https://doi.org/10.1371/journal.pntd.0006628
resource representing a document's title	Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge
has PubMed Central identifier	PMC6062107
has PubMed identifier	30011277
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:936e6e20342454e2646bd840d70148c893262146#body_text
is schema:about of	named entity 'fatal' named entity 'lethal' named entity 'rapid' named entity 'nature' named entity 'MICE' named entity 'PROTEIN ' named entity 'FEBRILE' covid:arg/936e6e20342454e2646bd840d70148c893262146 named entity 'RESULTS' named entity 'MODEL OF' named entity 'MAMMALS' named entity 'VIRAL DISEASE' named entity 'FUTURE' named entity 'VACCINE' named entity 'PROTECTION' named entity 'BASED' named entity 'BASED' named entity 'INCLUDING' named entity 'IMMUNOCOMPROMISED' named entity 'CRIMEAN-CONGO HEMORRHAGIC FEVER' named entity 'HERE' named entity 'ACUTE' named entity 'CLINICAL' named entity 'CCHFV' named entity 'CONSIDERED' named entity 'VACCINE' named entity 'MORTALITY' named entity 'ETIOLOGIC AGENT' named entity 'HEMORRHAGIC' named entity 'REPORT' named entity 'CASE REPORTS' named entity 'CONGO HEMORRHAGIC FEVER VIRUS' named entity 'NATURE' named entity 'PUBLIC HEALTH' named entity 'NUMBER OF' named entity 'TOTAL NUMBER' named entity 'CRIMEAN' named entity 'ADENOVIRUS' named entity 'DEVELOPMENT' named entity 'LETHAL' named entity 'ENDEMIC' named entity 'IMPORTED' named entity 'EFFICACY' named entity 'MICE' named entity 'AREAS' named entity 'PATIENTS' named entity 'ORTHONAIROVIRUS' named entity 'NUCLEOCAPSID PROTEIN' named entity 'ITS' named entity 'VACCINES' named entity 'FATAL' named entity 'TO PREVENT' named entity 'INFECT' named entity 'BURDEN' named entity 'INCREASED' named entity 'CHARACTERIZED' named entity 'EXPANSION' named entity 'ONSET OF' named entity 'INCREASE' named entity 'PAST' named entity 'MOUSE MODEL' named entity 'FOLLOWED BY' named entity 'STRATEGIES' named entity 'ASSESSMENT' named entity 'RAPID ONSET' named entity 'NUCLEOCAPSID PROTEIN' named entity 'CAUSE' named entity 'TREATMENTS' named entity 'MANIFESTATIONS' named entity 'SYMPTOMS' named entity 'CURRENTLY' named entity 'HUMANS' named entity 'DISEASE' named entity 'LICENSED' named entity 'PLATFORM' named entity 'PROVIDES' named entity 'CHALLENGE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software