About: Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors

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About: Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Creator	Herrmann, Andreas Ludwig, Kai Lauster, Daniel Block, Stephan Block, Nie, Chuanxiong Bhatia, S Nie, C Bhatia, Sumati Haag, Rainer Ludwig, Parshad, Badri Hilsch, Malte Wallert, Matthias Bçttcher, C Bçttcher, Christoph Cuellar-Camacho, J Haag, Herrmann, Hilsch, M Lauster, R Luis Cuellar-Camacho, Jose Parshad, M Wallert,
Source	Medline; PMC
abstract	Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC(50) values in low picomolar concentrations and also blocks the virus entry into MDCK‐II cells.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1002/anie.202006145
bibo:pmid	32441859
has license	cc-by
sha1sum (hex)	936da3a178fb68a51874e1d9874a07c3d39baa2b
schema:url	https://doi.org/10.1002/anie.202006145
resource representing a document's title	Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
has PubMed Central identifier	PMC7384064
has PubMed identifier	32441859
schema:publication	Angew Chem Int Ed Engl
resource representing a document's body	covid:936da3a178fb68a51874e1d9874a07c3d39baa2b#body_text
is schema:about of	named entity 'virus' named entity 'sialylated' named entity 'values' named entity 'Viral' named entity 'Infections' named entity 'DEFORM' named entity 'MDCK-II' named entity 'COMPARED' named entity 'SIZED' named entity 'ADAPT' named entity 'efficiently' named entity 'hemagglutinin' named entity 'virus' named entity 'assay' named entity 'sized' named entity 'adapts' named entity 'surface' named entity 'hemagglutination inhibition' named entity 'IAV' named entity 'nanogel' named entity 'influenza' named entity 'H3N2' named entity 'Nanogels' named entity 'Sialylated' named entity 'Viral Infections' named entity 'virus' named entity 'sialylated' named entity 'sialylated' named entity 'spectroscopy' named entity 'viral particles' named entity 'viral particles' named entity 'nanoparticles' named entity 'E. coli bacteria' named entity 'polymers' named entity 'NGs' named entity 'virus' named entity 'virus' named entity 'nanoparticles' named entity 'nanogels' named entity 'acetone' named entity 'assay' named entity 'infection' named entity 'On-rate' named entity 'kDa' named entity 'viruses' named entity 'dose-dependent manner' named entity 'micrometers' named entity 'S26' named entity 'polyglycerol' named entity 'click chemistry' named entity 'influenza A virus' named entity 'NGs' named entity 'viability assay' named entity 'sialylated' named entity 'nanoparticles' named entity 'pathogen' named entity 'sialylated' named entity 'infection'

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