About: Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

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About: Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
Creator	Lotze, Michael Brufsky, Adam Nasrazadani, Azadeh Luis Gomez Marti, Juan
Source	Medline; PMC
abstract	Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1186/s12967-020-02433-6
bibo:pmid	32600410
has license	cc-by
sha1sum (hex)	9363a3fc52f6e5803a2ea7ffb006ab82f67ab8be
schema:url	https://doi.org/10.1186/s12967-020-02433-6
resource representing a document's title	Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
has PubMed Central identifier	PMC7322393
has PubMed identifier	32600410
schema:publication	J Transl Med
resource representing a document's body	covid:9363a3fc52f6e5803a2ea7ffb006ab82f67ab8be#body_text
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