About: Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue

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About: Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue
Creator	Berg, J Guruprasad, K Machnik, C Open Access Citation ; Fatykhova, D Pache, F Rabes, A
Source	PMC
abstract	Streptococcus pneumoniae is a major cause of pneumonia, sepsis and meningitis. The pore-forming toxin pneumolysin is a key virulence factor of S. pneumoniae, which can be sensed by the NLRP3 inflammasome. Among the over 90 serotypes, serotype 1 pneumococci (particularly MLST306) have emerged across the globe as a major cause of invasive disease. The cause for its particularity is, however, incompletely understood. We therefore examined pneumococcal infection in human cells and a human lung organ culture system mimicking infection of the lower respiratory tract. We demonstrate that different pneumococcal serotypes differentially activate inflammasome-dependent IL-1β production in human lung tissue and cells. Whereas serotype 2, 3, 6B, 9N pneumococci expressing fully haemolytic pneumolysins activate NLRP3 inflammasome-dependent responses, serotype 1 and 8 strains expressing non-haemolytic toxins are poor activators of IL-1β production. Accordingly, purified haemolytic pneumolysin but not serotype 1-associated non-haemolytic toxin activates strong IL-1β production in human lungs. Our data suggest that the evasion of inflammasome-dependent innate immune responses by serotype 1 pneumococci might contribute to their ability to cause invasive diseases in humans.
has issue date	2015-08-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0137108
bibo:pmid	26317436
has license	cc-by
sha1sum (hex)	92f4de5e3cd8e63cd679d4af3db2d4d44e929ecd
schema:url	https://doi.org/10.1371/journal.pone.0137108
resource representing a document's title	Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue
has PubMed Central identifier	PMC4552725
has PubMed identifier	26317436
schema:publication	PLoS One
resource representing a document's body	covid:92f4de5e3cd8e63cd679d4af3db2d4d44e929ecd#body_text
is schema:about of	named entity 'SEROTYPE' named entity 'humans' named entity 'expressing' named entity 'haemolytic' named entity 'culture system' named entity 'sepsis' named entity 'activate' named entity 'PNEUMOCOCCAL INFECTION' named entity 'BUT' named entity 'INVASIVE DISEASE' named entity 'LUNG TISSUE' named entity 'PORE' named entity 'PNEUMOLYSIN' covid:arg/92f4de5e3cd8e63cd679d4af3db2d4d44e929ecd named entity 'DEPENDENT' named entity 'GLOBE' named entity 'HUMAN CELLS' named entity 'THE NLRP3 INFLAMMASOME' named entity 'FORMING' named entity 'SENSING' named entity 'EXAMINED' named entity 'HUMAN' named entity 'ITS' named entity 'LUNGS' named entity 'FULLY' named entity 'ORGAN CULTURE' named entity 'INFECTION' named entity 'ACROSS' named entity 'HUMANS' named entity 'LUNG TISSUE' named entity 'INFLAMMASOMES' named entity 'PNEUMOCOCCI' named entity 'HUMAN LUNG' named entity 'POOR' named entity 'TOXIN' named entity 'THEIR' named entity 'DISEASES' named entity 'IS A' named entity 'CONTRIBUTE ' named entity 'SEROTYPE' named entity 'TOXINS' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'DIFFERENT' named entity 'PRODUCTION' named entity 'INFLAMMASOME' named entity 'INVASIVE' named entity 'CELLS' named entity 'SUGGEST' named entity 'OUR' named entity 'SYSTEM' named entity 'PURIFIED' named entity 'SEROTYPES' named entity 'NON-HAEMOLYTIC' named entity 'PNEUMONIA' named entity 'CAUSE' named entity 'HAEMOLYTIC' named entity 'HUMAN LUNG' named entity 'SEPSIS' named entity 'IL-1' named entity 'STRAINS' named entity 'UNDERSTOOD' named entity 'VIRULENCE FACTOR' named entity 'DATA' named entity 'RESPONSES' named entity 'MENINGITIS' named entity 'LOWER RESPIRATORY TRACT' named entity 'ASSOCIATED' named entity 'KEY' named entity 'PNEUMOCOCCAL' named entity 'STRONG' named entity 'A MAJOR' named entity 'NLRP3' named entity 'IMMUNE RESPONSES' named entity 'ACTIVATE' named entity 'ACTIVATES' named entity 'HAVE'

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