About: Rhinovirus and Innate Immune Function of Airway Epithelium

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rhinovirus and Innate Immune Function of Airway Epithelium
Creator	Rajput, Charu Proud, David Upham, John Elzoheiry, Manal Ganjian, Haleh Sajjan, Umadevi
Source	Medline; PMC
abstract	Airway epithelial cells, which lines the respiratory mucosa is in direct contact with the environment. Airway epithelial cells are the primary target for rhinovirus and other inhaled pathogens. In response to rhinovirus infection, airway epithelial cells mount both pro-inflammatory responses and antiviral innate immune responses to clear the virus efficiently. Some of the antiviral responses include the expression of IFNs, endoplasmic reticulum stress induced unfolded protein response and autophagy. Airway epithelial cells also recruits other innate immune cells to establish antiviral state and resolve the inflammation in the lungs. In patients with chronic lung disease, these responses may be either defective or induced in excess leading to deficient clearing of virus and sustained inflammation. In this review, we will discuss the mechanisms underlying antiviral innate immunity and the dysregulation of some of these mechanisms in patients with chronic lung diseases.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.3389/fcimb.2020.00277
bibo:pmid	32637363
has license	cc-by
sha1sum (hex)	92c2d68fc174903a1cf6d7c3f5b1b6215850747f
schema:url	https://doi.org/10.3389/fcimb.2020.00277
resource representing a document's title	Rhinovirus and Innate Immune Function of Airway Epithelium
has PubMed Central identifier	PMC7316886
has PubMed identifier	32637363
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:92c2d68fc174903a1cf6d7c3f5b1b6215850747f#body_text
is schema:about of	named entity 'IFN' named entity 'RIG-I' named entity 'host cells' named entity 'innate immune responses' named entity 'infection' named entity 'NOS-2' named entity 'COPD' named entity 'airway epithelium' named entity 'epithelial cells' named entity 'anti-inflammatory' named entity 'luminol' named entity 'master regulator' named entity 'IFN-γ' named entity 'phenotype' named entity 'infection' named entity 'GCSF' named entity 'Enterovirus' named entity 'ER stress' named entity 'glycoprotein' named entity 'TLR2' named entity 'VP3' named entity 'RVs' named entity 'PD-L2' named entity 'Janus kinase' named entity 'cell surface' named entity 'lung inflammation' named entity 'UPR' named entity 'lung' named entity 'ILC2' named entity 'IP-10' named entity 'airway epithelium' named entity 'solute' named entity 'protein' named entity 'IFN-γ' named entity 'epithelial cells' named entity 'PERK' named entity 'TLR3' named entity 'alveoli' named entity 'cigarette smoke' named entity 'infection' named entity 'ER stress' named entity 'antiviral' named entity 'respiratory tract' named entity 'epithelial cells' named entity 'GRP' named entity 'CXCL-8' named entity 'epithelial cells' named entity 'oxidative stress' named entity 'epithelial cells' named entity 'UPR' named entity 'goblet cells' named entity 'lung disease' named entity 'host cells' named entity 'prostaglandin E2' named entity 'epithelial' named entity 'IFN' named entity 'hydrolases' named entity 'infection' named entity 'viruses' named entity 'nutrient deprivation' named entity 'interact' named entity 'autophagy' named entity 'double-stranded' named entity 'Tight junctions' named entity 'mucus layer' named entity 'epithelial cells' named entity 'autophagosome' named entity 'IRF3' named entity 'epithelial cells' named entity 'phosphatases' named entity 'COPD' named entity 'conjugated' named entity 'epithelial cells' named entity 'innate immune' named entity 'cytoplasm' named entity 'infection'

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