About: Highs and lows: Genetic susceptibility to daily events

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Highs and lows: Genetic susceptibility to daily events
Creator	Schlotz, Wolff Dieckmann, Linda Kumsta, Robert Luhmann, Maike Lux, Vanessa Moser, Dirk Neubauerid, Andreas Sicorelloid, Maurizio
source	Medline; PMC
abstract	Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person’s reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susceptibility factor for daily events. Participants (N = 326, 77% female, mean age = 25, range = 17–36) completed smartphone questionnaires four times a day over four to five days, measuring stressors, uplifts, positive and negative affect. Affect was predicted from environment valence in the previous hour on a within-person level using three-level autoregressive linear mixed models. The 5-HTTLPR fulfilled all criteria of a differential susceptibility factor: Positive affect in carriers of the short allele (S) was less reactive to both uplifts and stressors, compared to homozygous carriers of the long allele (L/L). This pattern might reflect relative affective inflexibility in S-allele carriers. Our study provides insight into the serotonin system’s general role in susceptibility and highlights the need to assess the whole spectrum of naturalistic experiences.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0237001
bibo:pmid	32790782
has license	cc-by
sha1sum (hex)	92b0719c1f2be20880f29908cf8a4ebf9a2b217f
schema:url	https://doi.org/10.1371/journal.pone.0237001
resource representing a document's title	Highs and lows: Genetic susceptibility to daily events
has PubMed Central identifier	PMC7425846
has PubMed identifier	32790782
schema:publication	PLoS One
resource representing a document's body	covid:92b0719c1f2be20880f29908cf8a4ebf9a2b217f#body_text
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