About: Structural characterization of the HCoV-229E fusion core

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About: Structural characterization of the HCoV-229E fusion core Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural characterization of the HCoV-229E fusion core
Creator	Zhang, Wei Rao, Zihe Yang, Haitao Chen, Xiaobo Yan, Mengrong Zheng, Qianqian Zhou, Weihong
Source	Elsevier; Medline; PMC
abstract	Abstract HCoV-229E spike (S) protein mediates virion attachment to cells and subsequent fusion of the viral and cellular membranes. This protein is composed of an N-terminal receptor-binding domain (S1) and a C-terminal trans-membrane fusion domain (S2). S2 contains a highly conserved heptad repeat 1 and 2 (HR1 and HR2). In this study, the HRs sequences were designed and connected with a flexible linker. The recombinant fusion core protein was crystallized and its structure was solved at a resolution of 2.45 Å. Then we characterized the binding of HR1s and HR2s via both sequence alignment and structural analysis. The overall structures, especially the residues in some positions of HR2 are highly conserved. Fourteen hydrophobic and three polar residues from each HR1 peptide are packed in layers at the coiled-coil interface. These core amino acids can be grouped into seven heptad repeats. Analysis of hydrophobic and hydrophilic interactions between HR2 helix and HR1 helices, shows that the HR1 and HR2 polypeptides are highly complementary in both shape and chemical properties. Furthermore, the available knowledge concerning HCoV-229E fusion core may make it possible to design small molecule or polypeptide drugs targeting membrane fusion, a crucial step of HCoV-229E infection.
has issue date	2018-03-04(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2018.02.136
bibo:pmid	29458023
has license	els-covid
sha1sum (hex)	929bcc7df412c79eac31f73c4fa3457559ef30c0
schema:url	https://doi.org/10.1016/j.bbrc.2018.02.136
resource representing a document's title	Structural characterization of the HCoV-229E fusion core
has PubMed Central identifier	PMC7092869
has PubMed identifier	29458023
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:929bcc7df412c79eac31f73c4fa3457559ef30c0#body_text
is schema:about of	named entity 'STRUCTURAL CHARACTERIZATION' named entity 'domain' named entity 'protein' named entity 'highly' named entity 'subsequent' named entity 'targeting' named entity 'N-terminal' named entity 'fusion' named entity 'SEVEN' named entity 'INTERFACE' named entity 'BINDING' named entity 'POLAR' named entity 'GROUPED' named entity 'INFECTION' named entity 'ANALYSIS' named entity 'MEDIATES' named entity 'RESOLUTION' named entity 'HELIX' named entity 'DRUGS TARGETING' named entity 'STRUCTURES' named entity 'PACKED' named entity 'AVAILABLE' named entity 'RECOMBINANT' named entity 'REPEATS' named entity '28S' named entity 'KNOWLEDGE' named entity 'CRYSTALLIZED' named entity 'CORE PROTEIN' named entity 'PEPTIDE' named entity 'POSSIBLE' named entity 'FOURTEEN' named entity 'SPIKE' named entity 'FLEXIBLE' named entity 'MEMBRANES' named entity 'CORE' named entity 'HCOV-229E' named entity 'FUSION' named entity 'DESIGN' named entity 'CORE' named entity 'N-TERMINAL ' named entity 'REPEAT' named entity 'MAKE' named entity 'CHEMICAL PROPERTIES' named entity 'MEMBRANE FUSION' named entity 'STRUCTURAL ANALYSIS' named entity 'RECEPTOR' named entity 'VIRAL AND' named entity 'CELLS' named entity 'LAYERS' named entity 'TRANS' named entity 'HRS' named entity 'POSITIONS' named entity 'PROTEIN ' named entity 'ITS' named entity 'SEQUENCES' named entity 'CONSERVED' named entity 'FUSION' named entity 'VIRION ATTACHMENT' named entity 'STEP' named entity 'OVERALL' named entity 'CELLULAR' named entity 'CHARACTERIZED' named entity 'HR1' named entity 'STRUCTURE' named entity 'AMINO ACIDS' named entity 'THESE' named entity 'STUDY' named entity 'HCOV-229E' named entity 'SEQUENCE ALIGNMENT' named entity 'HIGHLY' named entity 'POLYPEPTIDES' named entity 'HR2' named entity 'LINKER' named entity 'HYDROPHOBIC' named entity 'HELICES'

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