About: Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India

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About: Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India
Creator	Fathima, Saba Shobha, Vineeta Prakash, ·
Source	PMC
abstract	Granulomatosis with polyangiitis (GPA) previously known as Wegener’s granulomatosis is one of the forms of idiopathic systemic vasculitis. There is very scanty data available on GPA in Asian and Indian population. We studied data of 60 patients from southern India, diagnosed with GPA to describe the physical characteristics, the treatment, and outcome. Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Disease activity and damage were assessed by Birmingham Vasculitis Activity Score v. 3 (BVAS v. 3) and Vasculitis Damage Index (VDI), respectively. Relapses were defined as recurrence of GPA of sufficient severity to require treatment or increase in the dose of treatment on a patient who was previously stable. Out of 60 patients, initial BVAS evaluation showed that 57 (95%) patients had severe disease and 3 (5%) patients had limited disease where median BVAS was 21.5 (range 17–44). Follow-up BVAS evaluation for severe disease showed that 13 (22.8%) patients continued with severe disease of which 9 patients did not survive, 24 (42.3%) had remission, 11 (19.2%) had persistent disease, and 9 (15.7%) were lost to follow-up. The mean VDI score was 2.5 ± 2. Renal involvement was established in 42 (70%) patients. Upper and lower respiratory involvement was seen in 38 (63%) patients. Nervous system involvement was noted in the 15 (25%) patients. Articular manifestations were seen in 16 (27%) patients. Diverse clinical manifestation delay early diagnosis and treatment of this potentially treatable vasculitis. Focused approach could expedite early diagnosis and can reduce the mortality.
has issue date	2018-02-28(xsd:dateTime)
bibo:doi	10.1007/s10238-018-0492-7
bibo:pmid	29492716
has license	no-cc
sha1sum (hex)	924c07f1f98106995bd2f6290e913cbc67177fa4
schema:url	https://doi.org/10.1007/s10238-018-0492-7
resource representing a document's title	Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India
has PubMed Central identifier	PMC7102363
has PubMed identifier	29492716
schema:publication	Clin Exp Med
resource representing a document's body	covid:924c07f1f98106995bd2f6290e913cbc67177fa4#body_text
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