About: Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility
Creator	Chang, Wei-Chiao Hsu, Yu-Wen Huang, Ying-Hsien Kuo, Ho-Chang Yu, Hong-Ren Chien, Shu-Chen Hsieh, Kai-Sheng
Source	PMC
abstract	BACKGROUND: Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association between genetic polymorphisms of CD209 and the risk KD. METHODS: A total of 948 subjects (381 KD and 567 controls) were recruited. Nine tagging SNPs (rs8112310, rs4804800, rs11465421, rs1544766, rs4804801, rs2287886, rs735239, rs735240, rs4804804) were selected for TaqMan allelic discrimination assay. Clinical phenotypes, coronary artery lesions (CAL) and intravenous immunoglobulin (IVIG) treatment outcomes were collected for analysis. RESULTS: Significant associations were found between CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD. Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis. There were no significant association in KD with regards to CAL formation and IVIG treatment responses. CONCLUSION: CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness.
has issue date	2014-08-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0105236
bibo:pmid	25148534
has license	cc-by
sha1sum (hex)	9235d0eee63bf8da637b7b63b983d58d2372f0d3
schema:url	https://doi.org/10.1371/journal.pone.0105236
resource representing a document's title	Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility
has PubMed Central identifier	PMC4141786
has PubMed identifier	25148534
schema:publication	PLoS One
resource representing a document's body	covid:9235d0eee63bf8da637b7b63b983d58d2372f0d3#body_text
is schema:about of	named entity 'This' named entity 'susceptibility' named entity 'genetic polymorphisms' named entity 'CD209' named entity 'KAWASAKI DISEASE' named entity 'NON-' named entity 'AFFECTING' named entity 'SIGN' named entity 'SUSCEPTIBILITY' named entity 'STUDY' named entity 'BACKGROUND' named entity 'UNKNOWN ETIOLOGY' named entity 'CD209' named entity 'ASSOCIATED WITH' named entity 'GENETIC' named entity 'HUMANS' named entity 'CASCADE' named entity 'TRIGGER' named entity 'ASIAN COUNTRIES' named entity 'DENDRITIC CELL' named entity 'DISEASE SUSCEPTIBILITY' named entity 'IS A' named entity 'POLYMORPHISMS' named entity 'ASSOCIATED WITH' named entity 'GENETIC' named entity 'INTERCELLULAR ADHESION MOLECULE-3' named entity 'TO INVESTIGATE' named entity 'ASSOCIATION' named entity 'KAWASAKI DISEASE' named entity 'RISK' named entity 'SYSTEMIC VASCULITIS' named entity 'CD209' named entity 'INTEGRIN' named entity 'SPECIFIC' named entity 'VARIANTS' named entity 'CHILDREN' named entity 'ANTI-INFLAMMATORY' covid:arg/9235d0eee63bf8da637b7b63b983d58d2372f0d3 named entity 'Dendritic' named entity 'vasculitis' named entity 'cascade' named entity 'disease' named entity 'DC-SIGN' named entity 'Kawasaki disease' named entity 'integrin' named entity 'intercellular adhesion molecule' named entity 'etiology' named entity 'CD209' named entity 'Kawasaki Disease' named entity 'autoimmune' named entity 'CD209' named entity 'BLK' named entity 'Candida albicans' named entity 'antibody' named entity 'Beijing' named entity 'genotype' named entity 'inflammation' named entity 'immunosuppressive' named entity 'angioedema' named entity 'ethnic groups' named entity 'hands and feet' named entity '1.04' named entity 'CD40' named entity 'measles virus' named entity 'purulent' named entity 'Thermal Cycler' named entity 'antiinflammatory' named entity 'outpatient' named entity 'ITPKC' named entity 'IVIG' named entity 'HIV-1' named entity 'Allelic' named entity 'Helicobacter pylori' named entity 'skin rashes' named entity 'haplotypes'

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