About: Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays

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About: Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays
Creator	Karakitsos, P Chranioti, A Chrousos, G Kouni, S Michos, A Theodoridou, M
Source	Elsevier; Medline; PMC
abstract	The impact of viral co-infections and recently discovered viruses on the epidemiology of respiratory infections in children is still unclear. To simultaneously detect viruses that are involved in the aetiology of respiratory infections, we used a DNA/RNA microarray assay that identifies 17 different viruses or viral subtypes. Rhinopharyngeal washes were taken from 611 children (aged 1 month to 14 years) who presented in the emergency department with respiratory infections from June 2010 to June 2011 and were treated as outpatients (299, 48.9%) or hospitalized (312, 51.1%). Lower respiratory tract infection was diagnosed more often in hospitalized children (68% versus 36%, p 0.001). Of 397 children in which microarrays detected viral infection (70.1%), a single virus was found in 228 (57.4%) and two or more viruses in 169 (42.5%). The most prevalent viruses among children with positive samples were respiratory syncytial virus (RSV) in 225 (56.6%), parainfluenza virus (PIV) in 118 (29.7%), rhinovirus (RV) in 73 (18.4%), followed by influenza in 56 (14.1%), adenoviruses in 31 (7.8%), bocavirus in 25 (6.3%), human metapneumovirus in 15 (3.7%) and enteroviruses in 12 (3%). Most common viral co-infections were RSVA–RSVB in 46 children (27.2%), RSV–Influenza in 20 (11.8%), RSV–RV in 18 (10.6%) and PIV–RV in 13 (7.7%). Multiple logistic regression analysis revealed that viral co-infections were associated with increased probability for hospitalization (OR 1.52, 95% CI 1.01–2.29, p 0.04), and previous pneumococcal vaccination was associated with decreased probability for hospitalization (OR 0.52, 95% CI 0.33–0.81, p 0.004). We conclude that viral co-infections are involved in a significant proportion of children with an acute respiratory infection and may increase the severity of clinical presentation and the risk for hospitalization.
has issue date	2014-12-13(xsd:dateTime)
bibo:doi	10.1111/1469-0691.12015
bibo:pmid	23020634
has license	no-cc
sha1sum (hex)	922ebd7d82d6563c70d4cdb9501cfd26bc719cdd
schema:url	https://doi.org/10.1111/1469-0691.12015
resource representing a document's title	Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays
has PubMed Central identifier	PMC7129253
has PubMed identifier	23020634
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:922ebd7d82d6563c70d4cdb9501cfd26bc719cdd#body_text
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