About: Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital

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About: Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
Creator	Chang, Feng-Yee Chen, Jenn-Han Chiueh, Tzong-Shi Lin, Jung-Chung Chan, Paul Hu, Bor-Shen Lu, Jang-Jih Peng, Ming-Yieh Perng, Cherng-Lih Siu, L Wan, Hsiang-Lin Yeh, Kuo-Ming
source	Medline; PMC
abstract	Objectives: To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment. Methods: Convalescent plasma (500 mL) was obtained from each of three SARS patients and transfused into the three infected HCW. Donors were blood type O and seronegative for hepatitis B and C, HIV, syphilis and human T-cell lymphotropic virus types I and II (HTLV-I and -II). Serum antibody (IgG) titre was >640. Apharesis was performed with a CS 3000 plus cell separator followed by the forming of the convalescent phase plasma. As part of the routine check with donated plasma, the convalescent plasma was confirmed free of residual SARS-CoV by RT–PCR. Serial serum samples obtained from the recipients of the convalescent plasma were collected to undertake real-time quantitative RT–PCR for SARS-CoV for direct measurement of viral concentration. Specific immunoglobulin IgM and IgG concentrations were titrated using an antigen microarray developed in-house. Results: Viral load dropped from 495 × 10(3), 76 × 10(3) or 650 × 10(3) copies/mL to zero or 1 copy/mL one day after transfusion. Anti-SARS-CoV IgM and IgG also increased in a time-dependent manner following transfusion. All three patients survived. One HCW became pregnant subsequently, delivering 13 months after discharge. Positive anti-SARS-CoV IgG was detected in the newborn. Passive transfer of anti-SARS-CoV antibody from the mother was considered as a possibility. Conclusions: All infected HCW whose condition had progressed severely and who had failed to respond to the available treatment, survived after transfusion with convalescent plasma.
has issue date	2005-09-23(xsd:dateTime)
bibo:doi	10.1093/jac/dki346
bibo:pmid	16183666
has license	no-cc
sha1sum (hex)	922404670561476f77dc0eed27c01c7acbfaef75
schema:url	https://doi.org/10.1093/jac/dki346
resource representing a document's title	Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
has PubMed Central identifier	PMC7110092
has PubMed identifier	16183666
schema:publication	J Antimicrob Chemother
resource representing a document's body	covid:922404670561476f77dc0eed27c01c7acbfaef75#body_text
is schema:about of	named entity 'workers' named entity 'HOSPITAL' named entity 'CORONAVIRUS' named entity 'EXPERIENCE' named entity 'HEALTHCARE WORKERS' named entity 'HEALTHCARE WORKERS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'RESPONSES' named entity 'USING' named entity 'TAIWAN' named entity 'OBJECTIVES' named entity 'TREATMENT' named entity 'IMMUNOLOGICAL' named entity 'OUTCOME' named entity 'ADMINISTERED' named entity 'CLINICAL' named entity 'INFECTED' named entity 'TO DESCRIBE' named entity 'healthcare' named entity 'immunological' named entity 'coronavirus' named entity 'clinical outcome' named entity 'healthcare workers' named entity 'severe acute respiratory syndrome' named entity 'convalescent plasma' named entity 'HCW' named entity 'IgG antibody' named entity 'routine check' named entity 'vaccine' named entity 'RT-PCR' named entity 'SARS' named entity 'medical care' named entity 'viral infections' named entity 'recombinant' named entity 'SARS-CoV' named entity 'Serum' named entity 'signs of infection' named entity 'SARS' named entity 'SARS' named entity 'dyspnoea' named entity 'serum samples' named entity 'Serum' named entity 'human T-cell lymphotropic virus' named entity 'PBS' named entity 'isolation ward' named entity 'RT-PCR' named entity 'Coronavirus' named entity 'healthcare workers' named entity 'transfusion' named entity '10 December' named entity 'SARS' named entity 'SARS-CoV' named entity 'HCW' named entity 'Tween 20' named entity 'body temperature' named entity 'immunofluorescence assay' named entity 'seroconversion' named entity 'HCW' named entity 'convalescent plasma transfusion' named entity 'congenital infection' named entity 'pneumonia' named entity 'Serum' named entity 'phosphate-buffered saline' named entity 'HTLV-I' named entity 'ribavirin' named entity 'HCW' named entity 'immunoglobulins' named entity 'enzyme' named entity 'PBS' named entity 'sore throat'

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