About: Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation
Creator	Ibi, Daisuke Yamada, Kiyofumi Hashimoto, Kenji
Source	Medline; PMC
abstract	Increasing epidemiological evidence indicates that perinatal infection with various viral pathogens enhances the risk for several psychiatric disorders. The pathophysiological significance of astrocyte interactions with neurons and/or gut microbiomes has been reported in neurodevelopmental disorders triggered by pre- and postnatal immune insults. Recent studies with the maternal immune activation or neonatal polyriboinosinic polyribocytidylic acid models of neurodevelopmental disorders have identified various candidate molecules that could be responsible for brain dysfunction. Here, we review the functions of several candidate molecules in neurodevelopment and brain function and discuss their potential as therapeutic targets for psychiatric disorders.
has issue date	2015-11-27(xsd:dateTime)
bibo:doi	10.3390/ijms161226092
bibo:pmid	26633355
has license	cc-by
sha1sum (hex)	91e6020c65dd5a92c89040f9e209d65e26ef2b7f
schema:url	https://doi.org/10.3390/ijms161226092
resource representing a document's title	Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation
has PubMed Central identifier	PMC4691039
has PubMed identifier	26633355
schema:publication	Int J Mol Sci
resource representing a document's body	covid:91e6020c65dd5a92c89040f9e209d65e26ef2b7f#body_text
is schema:about of	named entity 'PERINATAL' named entity 'IMMUNE ACTIVATION' named entity 'neonatal' named entity 'neurodevelopmental disorders' named entity 'neurodevelopmental disorders' named entity 'Targets' named entity 'THEIR' named entity 'FUNCTIONS' named entity 'REPORTED' named entity 'IMMUNE ACTIVATION' named entity 'RECENT' named entity 'BRAIN DYSFUNCTION' named entity 'GUT' named entity 'PRE' named entity 'POTENTIAL' named entity 'HERE' named entity 'COULD BE' named entity 'NEURODEVELOPMENTAL DISORDERS' named entity 'INTERACTIONS' named entity 'NEONATAL' named entity 'MOLECULES' named entity 'HAVE' named entity 'PERINATAL INFECTION' named entity 'INCREASING' named entity 'BRAIN FUNCTION' named entity 'ASTROCYTE' named entity 'DISCUSS' named entity 'SIGNIFICANCE' named entity 'POLYRIBOCYTIDYLIC ACID' named entity 'THERAPEUTIC' named entity 'NEURODEVELOPMENTAL DISORDERS' named entity 'TARGETS' named entity 'MATERNAL' named entity 'NEURONS' named entity 'STUDIES' named entity 'EVIDENCE' named entity 'EPIDEMIOLOGICAL' named entity 'IMMUNE' named entity 'RISK' named entity 'VIRAL PATHOGENS' named entity 'AND BRAIN' named entity 'ANIMAL MODELS ' named entity 'REVIEW' named entity 'IDENTIFIED' named entity 'POSTNATAL' named entity 'MODELS' named entity 'CANDIDATE' named entity 'THERAPEUTIC' named entity 'TARGETS' named entity 'VARIOUS' named entity 'RESPONSIBLE' named entity 'NEURODEVELOPMENT' named entity 'TRIGGERED BY' named entity 'PSYCHIATRIC DISORDERS' named entity 'perinatal infection' named entity 'interactions' named entity 'psychiatric disorders' named entity 'postnatal' named entity 'morphological' named entity 'humoral' named entity 'IFITM3' named entity 'astrocytes' named entity 'astrocytes' named entity 'social interaction' named entity 'evidence' named entity 'astrocyte' named entity 'viral pathogens' named entity 'postnatal' named entity 'Therapeutic Targets' named entity 'MMP3' named entity 'TLRs' named entity 'antibody' named entity 'astrocytes' named entity 'postnatal' named entity 'brain development' named entity 'IL-6' named entity 'drug discovery' named entity 'neuronal development' named entity 'IFITM3'

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