About: Vaccine-induced enhancement of viral infections

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About: Vaccine-induced enhancement of viral infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccine-induced enhancement of viral infections
Creator	Osterhaus, A Rimmelzwaan, G Gruters, R Huisman, W Martina, B
Source	Elsevier; Medline; PMC
abstract	Abstract Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.
has issue date	2009-01-22(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2008.10.087
bibo:pmid	19022319
has license	els-covid
sha1sum (hex)	919375a1d0c4d7bb9230e44b929051aa0ca740e0
schema:url	https://doi.org/10.1016/j.vaccine.2008.10.087
resource representing a document's title	Vaccine-induced enhancement of viral infections
has PubMed Central identifier	PMC7131326
has PubMed identifier	19022319
schema:publication	Vaccine
resource representing a document's body	covid:919375a1d0c4d7bb9230e44b929051aa0ca740e0#body_text
is schema:about of	named entity 'feline immunodeficiency virus' named entity 'AIDS' named entity 'enhanced' named entity 'attributed' named entity 'induction' named entity 'enhancement' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'RATHER' named entity 'FAILURES' named entity 'ADE' named entity 'VIRUS INFECTION' named entity 'RECENT' named entity 'CERTAIN' named entity 'INDUCED' named entity 'BASIS' named entity 'ENHANCED' named entity 'DEVELOPMENT' named entity 'INFECTIONS' named entity 'LENTIVIRUS' named entity 'ABSENCE OF' named entity 'SUSCEPTIBILITY TO INFECTION' named entity 'VIRAL PATHOGENESIS' named entity 'REVIEWS' named entity 'CORONA' named entity 'FAMILIES' named entity 'SUCCESSFUL' named entity 'IMPORTANT' named entity 'ENHANCEMENT' named entity 'INDUCED' named entity 'VACCINE' named entity 'PLAYS' named entity 'INFECTION' named entity 'KNOWN' named entity 'ANTIBODY-DEPENDENT ENHANCEMENT' named entity 'DENGUE VIRUS' named entity 'LENTIVIRUS INFECTIONS' named entity 'POORLY' named entity 'VACCINE DEVELOPMENT' named entity 'PAPER' named entity 'PARTICULAR' named entity 'PRESENT' named entity 'GENERAL' named entity 'HAND' named entity 'DOCUMENTED' named entity 'HIV' named entity 'BLOCK' named entity 'A MAJOR' named entity 'VIRAL INFECTIONS' named entity 'ENHANCEMENT' named entity 'PHENOMENON' named entity 'SUSCEPTIBLE' named entity 'SUSCEPTIBILITY' named entity 'HAVE' named entity 'MEMBERS' named entity 'STUMBLE' named entity 'VACCINE' named entity 'DIFFERENT' named entity 'INDUCTION' named entity 'INVOLVED' named entity 'BALANCE' named entity 'SUBJECTS' named entity 'VACCINATED' named entity 'VIRUS' named entity 'MECHANISMS' named entity 'LIKE' named entity 'LITTLE' named entity 'VACCINES' named entity 'EXPERIMENTAL' named entity 'COMBINATION' named entity 'CURRENTLY' named entity 'PROTECTING' named entity 'UNDERSTOOD' named entity 'FELINE CORONAVIRUS' named entity 'ROLE' named entity 'ABERRANT' named entity 'VIRUSES' named entity 'PROTECTIVE IMMUNITY'

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