About: Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain

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About: Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain
Creator	Lu, Jia-Hai Cui, Zhiyong Qi, Shu-Yuan Xiong, Sheng Zhang, Biliang Wan, Zhuo-Yue Zheng, Huan-Ying Li, Jiu-Xiang Liu, Xin-Jian Wang, Yi-Fei Yan, Xin-Ge Zhang, Chuan-Hai Zhang, Mei-Ying
Source	Elsevier; Medline; PMC
abstract	Abstract The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(OH)3 adjuvant and CpG adjuvant). Titers of specific IgG antibodies in three test groups all peaked in the sixth week after first vaccination, but significant differences existed in the kinetics of specific IgG antibody levels. The strong neutralizing capacity exhibited in micro-cytopathic effect neutralization tests indicated the specific antibodies are protective. Western blot assay further demonstrated the specificity of the induced serum antibodies.
has issue date	2005-05-02(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2004.11.073
bibo:pmid	15837220
has license	els-covid
sha1sum (hex)	9189faee88e17c0cfdc158fc8aa8975850427cd1
schema:url	https://doi.org/10.1016/j.vaccine.2004.11.073
resource representing a document's title	Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain
has PubMed Central identifier	PMC7115646
has PubMed identifier	15837220
schema:publication	Vaccine
resource representing a document's body	covid:9189faee88e17c0cfdc158fc8aa8975850427cd1#body_text
is schema:about of	named entity 'PREPARED' named entity 'F69' covid:arg/9189faee88e17c0cfdc158fc8aa8975850427cd1 named entity 'MICE' named entity 'SARS-COV' named entity 'IMMUNE RESPONSES' named entity 'EVALUATED' named entity 'SPECIFIC' named entity 'CAPACITY' named entity 'NEUTRALIZATION TESTS' named entity 'LEVELS' named entity 'MICRO-' named entity 'BALB' named entity 'IMMUNIZATIONS' named entity 'STRAIN' named entity 'COMBINED' named entity 'SERUM' named entity 'F69' named entity 'SPECIFICITY' named entity 'ANTIBODIES' named entity 'VACCINE' named entity 'SARS-COV' named entity 'KINETICS' named entity 'INDICATED' named entity 'PREPARED' named entity 'SIXTH' named entity 'STRAIN' named entity 'CANDIDATE' named entity 'WESTERN BLOT ASSAY' named entity 'DEMONSTRATED' named entity 'TIMES' named entity 'SIGNIFICANT' named entity 'ADJUVANT' named entity 'INACTIVATED VACCINE' named entity 'IMMUNE RESPONSES' named entity 'GROUPS' named entity 'IGG ANTIBODY' named entity 'INDUCED' named entity 'TYPES' named entity 'BALB' named entity 'INDUCED' named entity 'INACTIVATED VACCINE' named entity 'ADJUVANTS' named entity 'IGG' named entity '27S' named entity 'PEAKED' named entity 'WEEK' named entity 'STRONG' named entity 'INTERVALS' named entity 'CANDIDATE' named entity 'BUT' named entity 'IMMUNOGENICITY' named entity 'TEST' named entity 'CPG' named entity 'VACCINATION' named entity 'MICE' named entity 'CYTOPATHIC EFFECT' named entity 'week' named entity 'The' named entity 'mice' named entity 'specific' named entity 'specific' named entity 'assay' named entity 'Immune' named entity 'SARS-CoV' named entity 'Balb/c' named entity 'antibodies' named entity 'Immune responses' named entity 'IgG'

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