About: Identification of a novel nidovirus in an outbreak of fatal respiratory disease in ball pythons (Python regius)

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About: Identification of a novel nidovirus in an outbreak of fatal respiratory disease in ball pythons (Python regius) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of a novel nidovirus in an outbreak of fatal respiratory disease in ball pythons (Python regius)
Creator	Jain, Komal Navarrete-Macias, Isamara Petrosov, Alexandra Tokarz, Rafal Uccellini, Lorenzo Buckles, Elizabeth Ec De Matos, Ricardo Hicks, Allison Lipkin, Walter Mcaloose, Denise Morrisey, James Ossiboff, Robert
topic	covid:9138f2909ac88cdf8463d08e4559197edc2c60ee#this
source	Medline; PMC
abstract	BACKGROUND: Respiratory infections are important causes of morbidity and mortality in reptiles; however, the causative agents are only infrequently identified. FINDINGS: Pneumonia, tracheitis and esophagitis were reported in a collection of ball pythons (Python regius). Eight of 12 snakes had evidence of bacterial pneumonia. High-throughput sequencing of total extracted nucleic acids from lung, esophagus and spleen revealed a novel nidovirus. PCR indicated the presence of viral RNA in lung, trachea, esophagus, liver, and spleen. In situ hybridization confirmed the presence of intracellular, intracytoplasmic viral nucleic acids in the lungs of infected snakes. Phylogenetic analysis based on a 1,136 amino acid segment of the polyprotein suggests that this virus may represent a new species in the subfamily Torovirinae. CONCLUSIONS: This report of a novel nidovirus in ball pythons may provide insight into the pathogenesis of respiratory disease in this species and enhances our knowledge of the diversity of nidoviruses.
has issue date	2014-08-08(xsd:dateTime)
bibo:doi	10.1186/1743-422x-11-144
bibo:pmid	25106433
has license	cc-by
sha1sum (hex)	9138f2909ac88cdf8463d08e4559197edc2c60ee
schema:url	https://doi.org/10.1186/1743-422x-11-144
resource representing a document's title	Identification of a novel nidovirus in an outbreak of fatal respiratory disease in ball pythons (Python regius)
has PubMed Central identifier	PMC4254391
has PubMed identifier	25106433
schema:publication	Virol J
resource representing a document's body	covid:9138f2909ac88cdf8463d08e4559197edc2c60ee#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/9138f2909ac88cdf8463d08e4559197edc2c60ee
is schema:about of	named entity 'FATAL' named entity 'identified' named entity 'In situ hybridization' named entity 'segment' named entity 'agents' named entity 'Python regius' named entity 'RESPIRATORY DISEASE' named entity 'CAUSES' named entity 'NEW SPECIES' named entity 'REPRESENT' named entity 'HIGH-THROUGHPUT SEQUENCING' named entity 'NOVEL' named entity 'PRESENCE OF' named entity 'BALL' named entity 'OUTBREAK' named entity 'RESPIRATORY INFECTIONS' named entity 'LIVER' named entity 'TRACHEITIS' named entity 'ESOPHAGUS' named entity 'SPLEEN' named entity 'PYTHONS' named entity 'SUBFAMILY TOROVIRINAE' named entity 'VIRUS' named entity 'PROVIDE' named entity 'POLYPROTEIN' named entity 'DIVERSITY' named entity 'BALL' named entity 'TRACHEA' named entity 'PHYLOGENETIC ANALYSIS' named entity 'INDICATED' named entity 'ESOPHAGITIS' named entity 'RESPIRATORY DISEASE' named entity 'PATHOGENESIS' named entity 'BASED' named entity 'BACKGROUND' named entity 'VIRAL RNA' named entity 'SNAKES' named entity 'PYTHONS' named entity 'EXTRACTED' named entity 'BACTERIAL PNEUMONIA' named entity 'INFECTED' named entity 'CONCLUSIONS' named entity 'INSIGHT' named entity 'SPECIES' named entity 'REPORTED' named entity 'REVEALED' named entity 'OUR' named entity 'IMPORTANT' named entity 'CONFIRMED' named entity 'FINDINGS' named entity 'PCR' named entity 'AMINO ACID' named entity 'VIRAL' named entity 'INTRACELLULAR' named entity 'EVIDENCE OF' named entity 'SEGMENT' named entity 'LUNG' named entity 'IN SITU HYBRIDIZATION' named entity 'IDENTIFIED' named entity 'THE LUNGS' named entity 'MORBIDITY AND MORTALITY' named entity 'REPTILES' named entity 'PNEUMONIA' named entity 'NUCLEIC ACIDS' named entity 'COLLECTION' named entity 'NOVEL' named entity 'REPORT' named entity 'KNOWLEDGE'

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