About: Endemic human coronaviruses induce distinct antibody repertoires in adults and children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Endemic human coronaviruses induce distinct antibody repertoires in adults and children
Creator	Marr, Nico Nasrallah, Gheyath Hasan, Mohammad Huang, Susie Al Ali, Fatima Khan, Taushif Rahman, Mahbuba Sayeed, Amira
Source	BioRxiv
abstract	Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans but immune responses to these “common cold” viruses remain incompletely understood. Moreover, there is evidence emerging from independent studies which suggests that endemic HCoVs can induce broadly cross-reactive T cell responses and may thereby affect clinical outcomes of acute infections with the phylogenetically related epidemic viruses, namely MERS-CoV and SARS-CoV-2. Here we report a comprehensive retrospective analysis of CoV-specific antibody specificities in a large number of samples from children and adults using Phage-Immunoprecipitation Sequencing (PhIP-Seq). We estimate the seroprevalence for endemic HCoVs to range from ~4% to ~27% depending on species and cohort. Most importantly, we identified a large number of novel linear B cell epitopes of HCoV proteins and demonstrate that antibody repertoires against endemic HCoVs are qualitatively different in children in comparison to the general adult population and healthy adult blood bank donors. We show that anti-HCoV IgG specificities more frequently found among children target functionally important and structurally conserved regions of the HCoV spike and nucleocapsid proteins and some antibody specificities are broadly cross-reactive with peptides of epidemic human and non-human coronavirus isolates. Our findings shed light on the humoral immune responses to natural infection with endemic HCoVs and may have important implications for understanding of the highly variable clinical outcomes of human coronavirus infections, for the development of prophylactic or therapeutic monoclonal antibodies and vaccine design.
has issue date	2020-06-22(xsd:dateTime)
bibo:doi	10.1101/2020.06.21.163394
has license	biorxiv
sha1sum (hex)	9123fecc03b363199ff3992418fa79906a7b7213
schema:url	https://doi.org/10.1101/2020.06.21.163394
resource representing a document's title	Endemic human coronaviruses induce distinct antibody repertoires in adults and children
schema:publication	bioRxiv
resource representing a document's body	covid:9123fecc03b363199ff3992418fa79906a7b7213#body_text
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