About: Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 Cells

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About: Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 Cells Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 Cells
Creator	Wang, Hongning Yang, Xin Gao, Wenqian Guan, Ru Han, Xiaoxiao Tian, Yiming Zhou, Long
Source	Medline; PMC
abstract	Avian infectious bronchitis has caused huge economic losses in the poultry industry. Previous studies have reported that infectious bronchitis virus (IBV) infection can produce cytopathic effects (CPE) and apoptosis in some mammalian cells and primary cells. However, there is little research on IBV-induced immune cell apoptosis. In this study, chicken macrophage HD11 cells were established as a cellular model that is permissive to IBV infection. Then, IBV-induced apoptosis was observed through a cell viability assay, morphological changes, and flow cytometry. The activity of caspases, the inhibitory efficacy of caspase-inhibitors and the expression of apoptotic genes further suggested the activation of apoptosis through both intrinsic and extrinsic pathways in IBV-infected HD11 cells. Additionally, ammonium chloride (NH(4)Cl) pretreated HD11 cells blocked IBV from entering cells and inhibited IBV-induced apoptosis. UV-inactivated IBV also lost the ability of apoptosis induction. IBV replication was increased by blocking caspase activation. This study presents a chicken macrophage cell line that will enable further analysis of IBV infection and offers novel insights into the mechanisms of IBV-induced apoptosis in immune cells.
has issue date	2017-07-26(xsd:dateTime)
bibo:doi	10.3390/v9080198
bibo:pmid	28933760
has license	cc-by
sha1sum (hex)	90672df8690ad900302e0e94fbe073b7cb762458
schema:url	https://doi.org/10.3390/v9080198
resource representing a document's title	Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 Cells
has PubMed Central identifier	PMC5580455
has PubMed identifier	28933760
schema:publication	Viruses
resource representing a document's body	covid:90672df8690ad900302e0e94fbe073b7cb762458#body_text
is schema:about of	named entity 'POULTRY INDUSTRY' named entity 'CELLULAR MODEL' named entity 'MACROPHAGE CELL LINE' named entity 'INDUCED' named entity 'LOST' named entity 'INTRINSIC' named entity 'PREVIOUS' named entity 'NOVEL' named entity 'EFFICACY' named entity 'MORPHOLOGICAL' named entity 'LITTLE' named entity 'REPORTED' named entity 'MAMMALIAN' named entity 'CHANGES' named entity 'APOPTOSIS' named entity 'AMMONIUM CHLORIDE' named entity 'INACTIVATED' named entity 'INHIBITORY' named entity 'MACROPHAGE' named entity 'EXTRINSIC' named entity 'macrophage' named entity 'caspase' named entity 'Macrophage' named entity 'VIRUS INFECTION' named entity 'HD11' named entity 'ABILITY' named entity 'STUDIES' named entity 'HAVE' named entity 'CELLS' named entity 'BLOCKING' named entity 'HUGE' named entity 'ENABLE' named entity 'ANALYSIS' named entity 'INFECTION' named entity 'INHIBITORS' named entity 'CELL VIABILITY ASSAY' named entity 'ACTIVATION OF APOPTOSIS' named entity 'MECHANISMS' named entity 'APOPTOSIS INDUCTION' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'CHICKEN' named entity 'REPLICATION' named entity 'CELLS' named entity 'APOPTOSIS' named entity 'PRESENTS' named entity 'ACTIVITY' named entity 'PRIMARY CELLS' named entity 'CASPASE ACTIVATION' named entity 'EXPRESSION' named entity 'FLOW CYTOMETRY' named entity 'PATHWAYS' named entity 'BLOCKED' named entity 'INCREASED' named entity 'OBSERVED' named entity 'CHICKEN' named entity 'REPLICATION' named entity 'ECONOMIC' named entity 'MACROPHAGE' named entity 'ESTABLISHED' named entity 'APOPTOTIC' named entity 'STUDY' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'GENES' named entity 'CAUSED' named entity 'CASPASES' named entity 'AVIAN INFECTIOUS BRONCHITIS' named entity 'RESEARCH' named entity 'INSIGHTS' named entity 'CASPASE' named entity 'A CELL' named entity 'PRODUCE' named entity 'INFECTED' named entity 'CYTOPATHIC EFFECTS' named entity 'IMMUNE CELLS' named entity 'IMMUNE CELL'

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