About: Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains

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About: Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains
Creator	Lorusso, Alessio David, Dan Savini, Giovanni Koren, Ori Bumbarov, Velizar Dagoni, Ilan Eldar, Avi Golender, N Golender, Natalia Gorohov, Anna Gorohov, Kaplan Gur, Iosef Hernandez, Jesus Js, Varsano Kalaiyarasu, Semmannan Kaplan, Alon Kenigswald, Gabriel Khinich, Yevgeny Meir, Abraham Oron, Eldad Schainin, Shani Sclamovich, Ily Shabbir, Muhammad Varsano, Joseph
Source	Medline; PMC
abstract	In this paper, the results of the diagnostic activities on Bluetongue virus serotype 3 (BTV-3) conducted at Kimron Veterinary Institute (Beit Dagan, Israel) between 2013 and 2018 are reported. Bluetongue virus is the causative agent of bluetongue (BT), a disease of ruminants, mostly transmitted by competent Culicoides species. In Israel, BTV-3 circulation was first detected in 2013 from a sheep showing classical BT clinical signs. It was also evidenced in 2016, and, since then, it has been regularly detected in Israeli livestock. Between 2013 and 2017, BTV-3 outbreaks were limited in sheep flocks located in the southern area only. In 2018, BTV-3 was instead found in the Israeli coastal area being one of the dominant BTV serotypes isolated from symptomatic sheep, cattle and goats. In Israeli sheep, BTV-3 was able to cause BT classical clinical manifestations and fatalities, while in cattle and goats infection ranged from asymptomatic forms to death cases, depending on either general welfare of the herds or on the occurrence of viral and bacterial co-infections. Three different BTV-3 strains were identified in Israel between 2013 and 2018: ISR-2019/13 isolated in 2013, ISR-2153/16 and ISR-2262/2/16 isolated in 2016. Sequencing and phylogenetic analysis of these strains showed more than 99% identity by segment (Seg) 2, 5, 6, 7, and 8 sequences. In contrast, a wide range of diversity among these strains was exhibited in other viral gene segments, implying the occurrence of genome reassortment between these local circulating strains and those originating from Africa. The genome sequences of the BTV-3 isolated in 2017 and 2018 were most closely related to those of the ISR-2153/16 strain suggesting their common ancestor. Comparison of BTV-3 Israeli strains with those recently detected in the Mediterranean region uncovered high percentage identity (98.19–98.28%) only between Seg-2 of all Israeli strains and the BTV-3 Zarzis/TUN2016 strain. A 98.93% identity was also observed between Seg-4 sequences of ISR-2019/13 and the BTV-3 Zarzis/TUN2016 strain. This study demonstrated that BTV-3 has been circulating in the Mediterranean region at least since 2013, but, unlike the other Mediterranean strains, Israeli BTV-3 were able to cause clinical signs also in cattle.
has issue date	2020-03-06(xsd:dateTime)
bibo:doi	10.3389/fvets.2020.00112
bibo:pmid	32211429
has license	cc-by
sha1sum (hex)	90637e4f46c7466511a622cb1cce5ed3c8eb4f3d
schema:url	https://doi.org/10.3389/fvets.2020.00112
resource representing a document's title	Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains
has PubMed Central identifier	PMC7068852
has PubMed identifier	32211429
schema:publication	Front Vet Sci
resource representing a document's body	covid:90637e4f46c7466511a622cb1cce5ed3c8eb4f3d#body_text
is schema:about of	named entity 'DISEASE' named entity 'STRAINS' named entity 'CLINICAL MANIFESTATIONS' named entity 'CHARACTERIZATION' named entity 'ISRAEL' named entity 'BLUETONGUE' named entity 'MOLECULAR' named entity '2018' named entity 'SEROTYPE' named entity 'ISRAELI' named entity 'tachycardia' named entity 'pathogenicity' named entity 'Nigerian' named entity 'vaccine' named entity 'cattle' named entity 'Qiagen' named entity 'hypothermia' named entity 'edema' named entity 'nasal discharge' named entity 'pyrexia' named entity 'Leipzig' named entity 'serotype' named entity 'placenta' named entity 'RNA' named entity 'Morbidity' named entity 'antibiotics' named entity 'Japan' named entity 'phylogenetic analyses' named entity 'viral disease' named entity 'virus' named entity 'white blood cells' named entity 'chicken' named entity '1, 2' named entity 'Geneious' named entity 'fetal tissues' named entity 'spleen' named entity 'embryo' named entity 'ketosis' named entity 'purulent' named entity 'reassortment' named entity 'phylogenetic analysis' named entity 'cattle' named entity 'NS3' named entity 'ruminants' named entity 'Zimbabwe' named entity 'North America' named entity 'virus' named entity 'edema' named entity 'Egypt' named entity 'ruminants' named entity 'pathogen' named entity 'RT-qPCR' named entity 'ketosis' named entity 'bovine' named entity 'Egypt' named entity 'salivation' named entity 'sheep' named entity 'notifiable disease'

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