About: Serum phosphorylated neurofilament heavy-chain levels reflect phenotypic heterogeneity and are an independent predictor of survival in motor neuron disease

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About: Serum phosphorylated neurofilament heavy-chain levels reflect phenotypic heterogeneity and are an independent predictor of survival in motor neuron disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serum phosphorylated neurofilament heavy-chain levels reflect phenotypic heterogeneity and are an independent predictor of survival in motor neuron disease
Creator	Agosta, Federica Barbieri, Alessandra Carrera, Paola Comi, Giancarlo Comola, Mauro Domi, Teuta Falzone, Yuri Fazio, Raffaella Filippi, Massimo Pozzi, Laura Quattrini, Angelo Riva, Nilo Schito, Paride Carro, Del Ubaldo, · Leocani, ·
Source	Medline; PMC
abstract	To investigate the prognostic role and the major determinants of serum phosphorylated neurofilament heavy -chain (pNfH) concentration across a large cohort of motor neuron disease (MND) phenotypes. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum pNfH concentration in 219 MND patients consecutively enrolled in our tertiary MND clinic. A multifactorial analysis was carried out to investigate the major clinical determinants of serum pNfH. Kaplan–Meier survival curves and Cox regression analysis were performed to explore the prognostic value of serum pNfH. Serum pNfH levels were not homogenous among MND phenotypes; higher concentrations in pyramidal, bulbar, and classic phenotypes were observed. C9orf72-MND exhibited higher pNfH concentrations compared to non-C9orf72 MND. Multiple linear regression analysis revealed mean MEP/cMAP and disease progression rate as the two major predictors of serum pNfH levels (R(2) = 0.188; p ≤ 0.001). Kaplan–Meier curves showed a significant difference of survival among MND subgroups when divided into quartiles based on pNfH concentrations, log-rank X(2) = 53.0, p ≤ 0.0001. Our study evidenced that higher serum pNfH concentration is a negative independent prognostic factor for survival. In Cox multivariate model, pNfH concentration showed the highest hazard ratio compared to the other factors influencing survival included in the analysis. pNfH differs among the MND phenotypes and is an independent prognostic factor for survival. This study provides supporting evidence of the role of pNfH as useful prognostic biomarker for MND patients. Neurofilament measurements should be considered in the future prognostic models and in clinical trials for biomarker-based stratification, and to evaluate treatment response. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00415-020-09838-9) contains supplementary material, which is available to authorized users.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1007/s00415-020-09838-9
bibo:pmid	32306171
has license	no-cc
sha1sum (hex)	90634ac1e98011423577b94c4b23626de3b63f5a
schema:url	https://doi.org/10.1007/s00415-020-09838-9
resource representing a document's title	Serum phosphorylated neurofilament heavy-chain levels reflect phenotypic heterogeneity and are an independent predictor of survival in motor neuron disease
has PubMed Central identifier	PMC7166001
has PubMed identifier	32306171
schema:publication	J Neurol
resource representing a document's body	covid:90634ac1e98011423577b94c4b23626de3b63f5a#body_text
is schema:about of	named entity 'revealed' named entity 'phenotypes' named entity 'study' named entity 'factors' named entity 'serum' named entity 'neurofilament' named entity 'evidence' named entity 'tertiary' named entity 'Cox regression' named entity 'hazard ratio' named entity 'prognostic' named entity 'prognostic' named entity 'neurofilament' named entity 'quartiles' named entity 'prognostic factor' named entity 'serum' named entity 'C9orf72' named entity 'MND' named entity 'survival' named entity 'Serum' named entity 'carried' named entity 'This' named entity 'levels' named entity 'MND' named entity 'serum' named entity 'concentration' named entity 'phosphorylated' named entity 'prognostic factor' named entity 'Enzyme-linked immunosorbent assay' named entity 'Multiple linear regression' named entity 'MND' named entity 'prognostic factor' named entity 'neurofilament' named entity 'MEP' named entity 'biomarker' named entity 'clinical trials' named entity 'MND' named entity 'treatment response' named entity 'serum' named entity 'phosphorylated' named entity 'heavy-chain' named entity 'phenotypic heterogeneity' named entity 'Serum' named entity 'motor neuron disease' named entity 'Phosphorylated' named entity 'logarithmic scale' named entity 'Cox proportional hazards model' named entity 'symptom' named entity 'serum' named entity 'stage 4' named entity 'ALS' named entity 'FTD' named entity 'FVC' named entity 'neurofilament' named entity 'venipuncture' named entity 'univariate analysis' named entity 'ALS' named entity 'neuropsychological assessment' named entity 'peripheral nerve stimulation' named entity 'primary lateral sclerosis' named entity 'motor neurons' named entity 'clinical characteristics' named entity 'serum' named entity 'stage 4' named entity 'cognitive dysfunction' named entity 'ALS'

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