About: SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

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About: SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease
Creator	Liu, Lihong Wang, Pengfei Wang, Qian Yu, Jian Luo, Yang Sodroski, Joseph Ho, David Laracy, Justin Nair, Manoj Yin, Michael Yuan, Ting Mori, Kanako Purpura, Lawrence Solis, Axel Yamashita, Masahiro
Source	BioRxiv
abstract	We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ~5-fold and ~7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
has issue date	2020-06-14(xsd:dateTime)
bibo:doi	10.1101/2020.06.13.150250
has license	biorxiv
sha1sum (hex)	8ff9e2360f815a3c0f97e51afda3679962bfd0d8
schema:url	https://doi.org/10.1101/2020.06.13.150250
resource representing a document's title	SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease
schema:publication	bioRxiv
resource representing a document's body	covid:8ff9e2360f815a3c0f97e51afda3679962bfd0d8#body_text
is schema:about of	named entity 'Patients' named entity 'virus' named entity 'Disease' named entity 'SARS-CoV-2' named entity 'SARS-CoV' named entity 'antibodies' named entity 'protein' named entity 'SARS-CoV-2' named entity 'plasma' named entity 'blood collection' named entity 'antibodies' named entity 'titer' named entity 'antibodies' named entity 'plasma' named entity 'virus' named entity 'immunoassay' named entity 'SARS-CoV' named entity 'pseudovirus' named entity 'SARS-CoV-2' named entity 'virus' named entity 'SARS-CoV' named entity 'plasma' named entity 'intensive care unit' named entity 'Cross-reactive' named entity 'antibodies' named entity 'plasma' named entity 'convalescent plasma' named entity 'serum samples' named entity 'infection' named entity 'binding antibody' named entity 'neutralizing antibodies' named entity 'monoclonal antibodies' named entity 'viremia' named entity 'SARS-CoV' named entity 'serologic' named entity 'SARS-CoV' named entity 'virus' named entity 'antibodies' named entity 'plasma' named entity 'virus' named entity 'Neutralizing Antibody' named entity 'pseudovirus' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'plasma' named entity 'serum samples' named entity 'glycoprotein' named entity 'Sarbecovirus' named entity 'neutralizing antibodies' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'coronaviruses' named entity 'virus' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'LOG' named entity '3 4' named entity 'virus' named entity 'PCR' named entity 'pseudovirus' named entity 'plasma' named entity 'SARS-CoV' named entity 'antibodies' named entity 'neutralizing antibody' named entity 'non-human primates' named entity 'plasma' named entity 'antibody' named entity 'SARS-CoV-2' named entity 'plasma' named entity 'HIV-1' named entity 'virus'

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