About: Translational Recoding Induced by G-Rich mRNA Sequences That Form Unusual Structures

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Translational Recoding Induced by G-Rich mRNA Sequences That Form Unusual Structures
Creator	Kollmus, Heike Horsburgh, Brian
Source	Elsevier; Medline; PMC
abstract	Abstract We investigated a herpesvirus mutant that contains a single base insertion in its thymidine kinase (tk) gene yet expresses low levels of TK via a net +1 translational recoding event. Within this mutant gene, we defined a G-rich signal that is sufficient to induce recoding. Unlike other translational recoding events, downstream RNA structures or termination codons did not stimulate recoding, and paused ribosomes were not detected. Mutational analysis indicated that specific tRNAs or codon–anticodon slippage were unlikely to account for recoding. Rather, recoding efficiency correlated with the G-richness of the signal and its ability to form unusual structures. These findings identify a mechanism of translational recoding with unique features and potential implications for clinical drug resistance and other biological systems.
has issue date	1996-09-20(xsd:dateTime)
bibo:doi	10.1016/s0092-8674(00)80170-1
bibo:pmid	8808630
has license	els-covid
sha1sum (hex)	8feebef712cb74f395a89a5b1b6a7f782a8904b2
schema:url	https://doi.org/10.1016/s0092-8674%2800%2980170-1
resource representing a document's title	Translational Recoding Induced by G-Rich mRNA Sequences That Form Unusual Structures
has PubMed Central identifier	PMC7126349
has PubMed identifier	8808630
schema:publication	Cell
resource representing a document's body	covid:8feebef712cb74f395a89a5b1b6a7f782a8904b2#body_text
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