About: Brain Meta-Transcriptomics from Harbor Seals to Infer the Role of the Microbiome and Virome in a Stranding Event

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About: Brain Meta-Transcriptomics from Harbor Seals to Infer the Role of the Microbiome and Virome in a Stranding Event Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Brain Meta-Transcriptomics from Harbor Seals to Infer the Role of the Microbiome and Virome in a Stranding Event
Creator	Vega Thurber, Rebecca Rosales, Stephanie
topic	covid:8fddf78a6b3a823c0ebeb2dfbfe274e46fee97f3#this
Source	Medline; PMC
abstract	Marine diseases are becoming more frequent, and tools for identifying pathogens and disease reservoirs are needed to help prevent and mitigate epizootics. Meta-transcriptomics provides insights into disease etiology by cataloguing and comparing sequences from suspected pathogens. This method is a powerful approach to simultaneously evaluate both the viral and bacterial communities, but few studies have applied this technique in marine systems. In 2009 seven harbor seals, Phoca vitulina, stranded along the California coast from a similar brain disease of unknown cause of death (UCD). We evaluated the differences between the virome and microbiome of UCDs and harbor seals with known causes of death. Here we determined that UCD stranded animals had no viruses in their brain tissue. However, in the bacterial community, we identified Burkholderia and Coxiella burnetii as important pathogens associated with this stranding event. Burkholderia were 100% prevalent and ~2.8 log2 fold more abundant in the UCD animals. Further, while C. burnetii was found in only 35.7% of all samples, it was highly abundant (~94% of the total microbial community) in a single individual. In this harbor seal, C. burnetii showed high transcription rates of invading and translation genes, implicating it in the pathogenesis of this animal. Based on these data we propose that Burkholderia taxa and C. burnetii are potentially important opportunistic neurotropic pathogens in UCD stranded harbor seals.
has issue date	2015-12-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0143944
bibo:pmid	26630132
has license	cc-by
sha1sum (hex)	8fddf78a6b3a823c0ebeb2dfbfe274e46fee97f3
schema:url	https://doi.org/10.1371/journal.pone.0143944
resource representing a document's title	Brain Meta-Transcriptomics from Harbor Seals to Infer the Role of the Microbiome and Virome in a Stranding Event
has PubMed Central identifier	PMC4668051
has PubMed identifier	26630132
schema:publication	PLoS One
resource representing a document's body	covid:8fddf78a6b3a823c0ebeb2dfbfe274e46fee97f3#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/8fddf78a6b3a823c0ebeb2dfbfe274e46fee97f3
is schema:about of	named entity 'KNOWN' named entity 'BRAIN TISSUE' named entity 'BRAIN DISEASE' named entity 'SIMILAR' named entity 'TAXA' named entity 'UCDS' named entity 'INSIGHTS' named entity 'DATA' named entity 'SIMULTANEOUSLY' named entity 'FOUND' named entity 'VIRUSES' named entity 'EVENT' named entity 'THESE' named entity 'THEIR' named entity 'CAUSES OF DEATH' named entity 'BASED' named entity 'SYSTEMS' named entity 'SINGLE' named entity 'COAST' named entity 'SEALS' named entity 'DETERMINED' named entity 'META' named entity 'TRANSCRIPTOMICS' named entity 'VIRAL AND' named entity 'COMMUNITIES' named entity 'HARBOR' named entity 'Burkholderia' named entity 'simultaneously' named entity 'genes' named entity 'evaluated' named entity 'stranding' named entity 'identified' named entity 'UCD' named entity 'bacterial' named entity 'neurotropic' named entity 'META' named entity 'SEQUENCES' named entity 'TECHNIQUE' named entity 'MARINE' named entity 'RATES' named entity 'UCD' named entity 'CALIFORNIA' named entity 'FREQUENT' named entity 'IS A' named entity 'COMPARING' named entity 'DISEASE RESERVOIRS' named entity 'TOOLS' named entity 'ABUNDANT' named entity 'SUSPECTED' named entity 'APPROACH' named entity 'TO HELP' named entity 'PATHOGENESIS' named entity 'MITIGATE' named entity 'HAVE' named entity 'EPIZOOTICS' named entity 'GENES' named entity 'EVENT' named entity 'MICROBIOME' named entity 'INFER' named entity 'BRAIN' named entity 'TRANSCRIPTOMICS' named entity 'BUT' named entity 'NEUROTROPIC' named entity 'TRANSCRIPTION' named entity 'HARBOR' named entity 'LOG2' named entity 'APPLIED' named entity 'METHOD' named entity 'INDIVIDUAL' named entity 'POWERFUL' named entity 'STUDIES' named entity 'HIGH' named entity '100%' named entity 'PREVENT' named entity 'HIGHLY' named entity 'MICROBIAL COMMUNITY' named entity 'BACTERIAL COMMUNITY' named entity 'ASSOCIATED WITH'

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