About: Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity

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About: Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity
Creator	Aldabbagh, S Boesecke, C Diegmann, C Eis-Hübinger, A.-M Eschbach-Bludau, M Marx, B Ohla, € Richter, E Schmithausen, R Schulte, B Sib, E Streeck, H
Source	Elsevier; Medline; PMC
abstract	Abstract Objective With the current SARS-CoV2 outbreak, countless tests need to be performed on potential symptomatic individuals, contacts and travellers. The gold standard is a quantitative polymerase chain reaction (qPCR)–based system taking several hours to confirm positivity. For effective public health containment measures, this time span is too long. We therefore evaluated a rapid test in a high-prevalence community setting. Study design Thirty-nine randomly selected individuals at a COVID-19 screening centre were simultaneously tested via qPCR and a rapid test. Ten previously diagnosed individuals with known SARS-CoV-2 infection were also analysed. Methods The evaluated rapid test is an IgG/IgM–based test for SARS-CoV-2 with a time to result of 20 min. Two drops of blood are needed for the test performance. Results Of 49 individuals, 22 tested positive by repeated qPCR. In contrast, the rapid test detected only eight of those positive correctly (sensitivity: 36.4%). Of the 27 qPCR-negative individuals, 24 were detected correctly (specificity: 88.9%). Conclusion Given the low sensitivity, we recommend not to rely on an antibody-based rapid test for public health measures such as community screenings.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1016/j.puhe.2020.04.009
bibo:pmid	32334183
has license	els-covid
sha1sum (hex)	8fa9ceafcec7846f5b3e8800777aec7d781ddf93
schema:url	https://doi.org/10.1016/j.puhe.2020.04.009
resource representing a document's title	Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity
has PubMed Central identifier	PMC7165286
has PubMed identifier	32334183
schema:publication	Public Health
resource representing a document's body	covid:8fa9ceafcec7846f5b3e8800777aec7d781ddf93#body_text
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