About: Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury
Creator	Bachmaier, Kurt Malik, Asrar Maienschein-Cline, Mark Stuart, Andrew Chakraborty, Sreeparna Gao, Xiaopei Hong, Zhigang Kanteti, Prasad Mukhopadhyay, Amitabha Rehman, Jalees Singh, Abhalaxmi Tsukasaki, Yoshikazu
Source	BioRxiv
abstract	Inflammatory tissue injury such as acute lung injury (ALI) is a disorder that leads to respiratory failure, a major cause of morbidity and mortality worldwide. Excessive neutrophil influx is a critical pathogenic factor in the development of ALI. Here, we identify the subset of neutrophils that is responsible for ALI and lethality in polymicrobial sepsis. The pro-inflammatory neutrophil subpopulation was characterized by its unique ability to endocytose albumin nanoparticles (ANP), upregulation of pro-inflammatory cytokines and chemokines as well as the excessive production of reactive oxygen species (ROS) in models of endotoxemia and septicemia. ANP delivery of the drug piceatannol, a spleen tyrosine kinase (Syk) inhibitor, to the susceptible subset of neutrophils, prevented ALI and mortality in mice subjected to polymicrobial infection. Targeted inhibition of Syk in ANP-susceptible neutrophils had no detrimental effect on neutrophil-dependent host defense because the subset of ANPlow neutrophils effectively controlled polymicrobial infection. The results show that neutrophil heterogeneity can be leveraged therapeutically to prevent ALI without compromising host defense.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1101/2020.06.30.180927
has license	biorxiv
sha1sum (hex)	8f9703a1d10ee7cac65e322ac3b11f6905c6149a
schema:url	https://doi.org/10.1101/2020.06.30.180927
resource representing a document's title	Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury
schema:publication	bioRxiv
resource representing a document's body	covid:8f9703a1d10ee7cac65e322ac3b11f6905c6149a#body_text
is schema:about of	named entity 'ALI' named entity 'ALI' named entity 'neutrophils' named entity 'sepsis' named entity 'lethality' named entity 'tissue injury' named entity 'acute lung injury' named entity 'microvasculature' named entity 'LPS' named entity 'lung inflammation' named entity 'macrophages' named entity 'PMN' named entity 'neutrophils' named entity 'PMN' named entity 'neutrophils' named entity 'ANP' named entity 'nos2' named entity 'survival rate' named entity 'neutrophilic' named entity 'endotoxemia' named entity 'endocytosed' named entity 'transcriptomic' named entity 'iNOS' named entity 'single cell' named entity 'hyperinflammation' named entity 'ANP' named entity 'PMN' named entity 'Ccr7' named entity 'ANP' named entity 'pneumonia' named entity 'Syngeneic' named entity 'ANP' named entity 'cytokine' named entity 'steady-state' named entity 'Ccrl2' named entity 'host defense' named entity 'parenchymal cells' named entity 'cytokines' named entity 'ROS' named entity 'Peroxynitrite' named entity 'adoptive transfer' named entity 'piceatannol' named entity 'cell damage' named entity 'neutrophilic' named entity 'ANP' named entity 'endocytosed' named entity 'Mac-1' named entity 'cytokine storm' named entity 'CD11b' named entity 'Ccl6' named entity 'PMN' named entity 'laparotomy' named entity 'chemokine receptors' named entity 'PMN' named entity 'sepsis' named entity 'Amplex' named entity 'PMN' named entity 'dendrogram' named entity 'tissue damage' named entity 'ANP' named entity 'CCL3' named entity 'mRNA expression' named entity 'staining' named entity 'Ccr10' named entity 'CD1' named entity 'LPS' named entity 'liver' named entity 'mice' named entity 'cytokines' named entity 'ANP' named entity 'RNA-Seq' named entity 'inflammatory conditions' named entity 'mice'

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