About: Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

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About: Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine
Creator	Arabi, Yaseen Gunst, Jan Wilmer, Alexander Bear, Danielle Benstoem, Carina Berger, Mette Casaer, Michael Deane, Adam Elke, Gunnar Fruhwald, Sonja Fuhrmann, Valentin Jakob, Stephan Kott, Matthias Lautenschläger, Ingmar Loudet, Cecilia Nobile, Leda Oudemans-Van Straaten, Heleen Preiser, Jean-Charles Reintam Blaser, Annika Rooyackers, Olav Schäper, Jörn Starkopf, Joel Stoppe, Christian Van Zanten, Arthur Wernerman, Jan
Source	PMC
abstract	BACKGROUND: Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We aimed to develop a research agenda for GI dysfunction for future research. We systematically reviewed the current knowledge on a broad range of subtopics from a specific viewpoint of GI dysfunction, highlighting the remaining areas of uncertainty and suggesting future studies. METHODS: This systematic scoping review and research agenda was conducted following successive steps: (1) identify clinically important subtopics within the field of GI function which warrant further research; (2) systematically review the literature for each subtopic using PubMed, CENTRAL and Cochrane Database of Systematic Reviews; (3) summarize evidence for each subtopic; (4) identify areas of uncertainty; (5) formulate and refine study proposals that address these subtopics; and (6) prioritize study proposals via sequential voting rounds. RESULTS: Five major themes were identified: (1) monitoring, (2) associations between GI function and outcome, (3) GI function and nutrition, (4) management of GI dysfunction and (5) pathophysiological mechanisms. Searches on 17 subtopics were performed and evidence summarized. Several areas of uncertainty were identified, six of them needing consensus process. Study proposals ranked among the first ten included: prevention and management of diarrhoea; management of upper and lower feeding intolerance, including indications for post-pyloric feeding and opioid antagonists; acute gastrointestinal injury grading as a bedside tool; the role of intra-abdominal hypertension in the development and monitoring of GI dysfunction and in the development of non-occlusive mesenteric ischaemia; and the effect of proton pump inhibitors on the microbiome in critical illness. CONCLUSIONS: Current evidence on GI dysfunction is scarce, partially due to the lack of precise definitions. The use of core sets of monitoring and outcomes are required to improve the consistency of future studies. We propose several areas for consensus process and outline future study projects.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1186/s13054-020-02889-4
bibo:pmid	32414423
has license	cc-by
sha1sum (hex)	8f7fbcb73ef7af430be0b5aeb4978b61b09a7b26
schema:url	https://doi.org/10.1186/s13054-020-02889-4
resource representing a document's title	Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine
has PubMed Central identifier	PMC7226709
has PubMed identifier	32414423
schema:publication	Crit Care
resource representing a document's body	covid:8f7fbcb73ef7af430be0b5aeb4978b61b09a7b26#body_text
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