About: Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study
Creator	Blanquer, José Rello, Jordi Solé-Violán, Jordi Aspa, Javier Rajas, Olga Rodríguez De Castro, Felipe Borderías, Luis Ferrer, José González-Quevedo, Nereida Herrera-Ramos, Estefanía Rodríguez-Gallego, Carlos Saavedra, Pedro Sologuren, Ithaisa Briones, Luisa García-Laorden, Isabel Marcos-Ramos, Alberto
source	PMC
abstract	INTRODUCTION: Genetic variability of the pulmonary surfactant proteins A and D may affect clearance of microorganisms and the extent of the inflammatory response. The genes of these collectins (SFTPA1, SFTPA2 and SFTPD) are located in a cluster at 10q21-24. The objective of this study was to evaluate the existence of linkage disequilibrium (LD) among these genes, and the association of variability at these genes with susceptibility and outcome of community-acquired pneumonia (CAP). We also studied the effect of genetic variability on SP-D serum levels. METHODS: Seven non-synonymous polymorphisms of SFTPA1, SFTPA2 and SFTPD were analyzed. For susceptibility, 682 CAP patients and 769 controls were studied in a case-control study. Severity and outcome were evaluated in a prospective study. Haplotypes were inferred and LD was characterized. SP-D serum levels were measured in healthy controls. RESULTS: The SFTPD aa11-C allele was significantly associated with lower SP-D serum levels, in a dose-dependent manner. We observed the existence of LD among the studied genes. Haplotypes SFTPA1 6A(2 )(P = 0.0009, odds ration (OR) = 0.78), SFTPA2 1A(0 )(P = 0.002, OR = 0.79), SFTPA1-SFTPA2 6A(2)-1A(0 )(P = 0.0005, OR = 0.77), and SFTPD-SFTPA1-SFTPA2 C-6A(2)-1A(0 )(P = 0.00001, OR = 0.62) were underrepresented in patients, whereas haplotypes SFTPA2 1A(10 )(P = 0.00007, OR = 6.58) and SFTPA1-SFTPA2 6A(3)-1A (P = 0.0007, OR = 3.92) were overrepresented. Similar results were observed in CAP due to pneumococcus, though no significant differences were now observed after Bonferroni corrections. 1A(10 )and 6A-1A were associated with higher 28-day and 90-day mortality, and with multi-organ dysfunction syndrome (MODS) and acute respiratory distress syndrome (ARDS) respectively. SFTPD aa11-C allele was associated with development of MODS and ARDS. CONCLUSIONS: Our study indicates that missense single nucleotide polymorphisms and haplotypes of SFTPA1, SFTPA2 and SFTPD are associated with susceptibility to CAP, and that several haplotypes also influence severity and outcome of CAP.
has issue date	2011-02-10(xsd:dateTime)
bibo:doi	10.1186/cc10030
bibo:pmid	21310059
has license	cc-by
sha1sum (hex)	8f4a004209c6ba0dccef04dd78c2caf7ea0bda3c
schema:url	https://doi.org/10.1186/cc10030
resource representing a document's title	Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study
has PubMed Central identifier	PMC3221990
has PubMed identifier	21310059
schema:publication	Crit Care
resource representing a document's body	covid:8f4a004209c6ba0dccef04dd78c2caf7ea0bda3c#body_text
is schema:about of	named entity 'prospective study' named entity 'SFTPA1' named entity 'inflammatory response' named entity 'cluster' named entity 'polymorphisms' named entity 'linkage disequilibrium' named entity '769' named entity 'PULMONARY SURFACTANT' named entity 'GENETIC VARIABILITY' named entity 'ANALYZED' named entity '10Q21' covid:arg/8f4a004209c6ba0dccef04dd78c2caf7ea0bda3c named entity 'extent' named entity 'measured' named entity 'genes' named entity 'microorganisms' named entity 'SFTPA2' named entity 'Genetic variability' named entity 'genetic variability' named entity 'Haplotypes' named entity 'linkage disequilibrium' named entity 'prospective study' named entity 'CAP' named entity 'SFTPA1' named entity 'collectins' named entity 'polymorphisms' named entity 'genetic variability' named entity 'surfactant proteins' named entity 'The' named entity 'infectious diseases' named entity 'CAP' named entity 'collagen' named entity 'collectins' named entity 'CAP' named entity 'SNPs' named entity 'SP-A' named entity 'haplotypes' named entity 'Caucasoid' named entity 'monomeric' named entity 'SFTPA1' named entity 'haplotypes' named entity 'haplotypes' named entity 'nucleotide sequences' named entity 'CAP' named entity 'gene' named entity 'CAP' named entity 'dominant and recessive' named entity 'mice' named entity 'haplotype' named entity 'haplotypes' named entity 'SFTPA1' named entity 'SFTPA2' named entity 'MODS' named entity 'CAP' named entity 'opsonization' named entity 'haplotypes' named entity 'haplotypes' named entity 'recessive' named entity 'microorganism' named entity 'SNPs' named entity 'pathogens' named entity 'SFTPA2' named entity 'recombinant' named entity 'SNPs' named entity 'P-value' named entity 'Toll-like receptors'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software