About: Inhibition of Junín virus replication by small interfering RNAs

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About: Inhibition of Junín virus replication by small interfering RNAs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of Junín virus replication by small interfering RNAs
Creator	Scolaro, Luis Artuso, María Damonte, Elsa Ellenberg, Paula García, Cybele
Source	Elsevier; Medline; PMC
abstract	Abstract Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z arenavirus matrix protein represents an attractive target for antiviral therapy. With the aim of studying a new alternative therapeutic mechanism, four Z-specific siRNAs (Z1- to Z4-siRNAs) were tested showing variable efficacy. The most effective inhibitor was Z2-siRNA targeted at the region encompassed by nt 179–197 of Z gene. The efficacy of this Z2-siRNA against JUNV was also demonstrated in virus-infected cells, by testing infectious virus plaque formation (92.8% JUNV yield reduction), viral RNA level or antigen expression, as well as in cells transfected with Z-specific reporter plasmids (91% reduction in expression of Z-EGFP fusion protein). Furthermore, the lack of effect of this Z-siRNA on the expression of other JUNV proteins, such as N and GPC, confirmed the specificity of action exerted by Z2-siRNA on Z transcript. Thus, the present study represents the first report of virus inhibition mediated by RNA interference for a New World arenavirus.
has issue date	2009-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2009.07.001
bibo:pmid	19591878
has license	els-covid
sha1sum (hex)	8f4376eb10f5bc89293efc5a2059e4b871684236
schema:url	https://doi.org/10.1016/j.antiviral.2009.07.001
resource representing a document's title	Inhibition of Junín virus replication by small interfering RNAs
has PubMed Central identifier	PMC7114203
has PubMed identifier	19591878
schema:publication	Antiviral Research
resource representing a document's body	covid:8f4376eb10f5bc89293efc5a2059e4b871684236#body_text
is schema:about of	named entity 'represents' named entity 'virus' named entity 'demonstrated' named entity 'cells' named entity 'expression' named entity 'VIRUS REPLICATION' named entity 'INHIBITOR' named entity 'ARENAVIRUS' named entity 'HAVE' named entity 'REPORT' named entity 'ARGENTINE HEMORRHAGIC FEVER' named entity 'TESTED' named entity 'INFECTED' named entity 'REPORTER' named entity 'REGION' named entity 'PRESENT' named entity 'JUN' named entity 'INHIBITION' named entity 'PROTEINS' named entity 'LEVEL' named entity 'EFFICACY' named entity 'ACTION' named entity 'EFFECT' named entity 'ANTIGEN' named entity 'TRANSCRIPT' named entity 'AGENT' named entity 'EFFECTIVE' named entity 'TARGETED' named entity 'VIRUS' named entity 'WORKS' covid:arg/8f4376eb10f5bc89293efc5a2059e4b871684236 named entity 'PROTEIN ' named entity 'LACK' named entity 'EXERTED' named entity 'NEW' named entity 'ATTRACTIVE' named entity 'NEW WORLD ARENAVIRUS' named entity 'SPECIFIC' named entity 'GENE' named entity 'VIRAL RNA' named entity 'STUDY' named entity 'INFECTIOUS' named entity 'EGFP' named entity 'VARIABLE' named entity 'THERAPEUTIC' named entity 'CELLS' named entity 'SMALL INTERFERING RNAS' named entity 'JUN' named entity 'FORMATION' named entity 'INHIBITION' named entity 'TARGET' named entity 'MEDIATED' named entity '179' named entity 'TESTING' named entity 'EXPRESSION' named entity 'AIM' named entity 'PREVIOUS' named entity 'PLAQUE' named entity 'RNA INTERFERENCE' named entity 'SIRNAS' named entity 'ADN' named entity 'MATRIX PROTEIN' named entity 'ADN' named entity 'ANTIVIRAL THERAPY' named entity 'MECHANISM' named entity 'SIRNA' named entity 'FUSION PROTEIN' named entity 'GPC' named entity 'SINGLE-STRANDED RNA' named entity 'SPECIFICITY' named entity 'REDUCTION' named entity 'ALTERNATIVE' named entity 'YIELD' named entity 'CONFIRMED' named entity 'PLASMIDS' named entity 'DEMONSTRATED' named entity 'tested'

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