About: The Spectrum of Clinical and Serological Features of COVID-19 in Urban Hemodialysis Patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Spectrum of Clinical and Serological Features of COVID-19 in Urban Hemodialysis Patients
Creator	Ortiz, Alberto Avello, Alejandro Gomá-Garcés, Elena González-Parra, Emilio Mas-Fontao, Sebastian »more»
source	Medline; PMC
abstract	Introduction: The inherent immunosuppression of uremia increases the susceptibility of hemodialysis patients to infection. There is still limited evidence on hemodialysis patients and COVID-19. The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. Material and Methods: Clinical and analytical features, chest X-ray, polymerase chain reaction (PCR) and antibodies for SARS-CoV-2, treatment and outcomes were analyzed in 48 patients diagnosed with COVID-19 during March and April 2020 in two coordinated Spanish hemodialysis units. Results: In 200 haemodialysis patients, COVID-19 was diagnosed in 48, of whom 22 were PCR positive, eight PCR negative but seroconverted and two were diagnosed on typical clinical grounds. Despite a mean age of 72.6 years, the overall mortality rate was 5/48 (10%). Among the PCR positive patients, 21 (55%) required admission and five (13%) died. PCR positive patients were more often symptomatic and hospitalized and had higher troponin I levels than PCR negative patients, but did not differ in lymphocyte counts, D-dimer or interleukin-6 (IL-6) levels. Among PCR negative COVID-19 patients, three out of 10 (30%) required admission, and none died. The most frequent symptom among the 48 patients was fever (31%), followed by asymptomatic patients (23%). A low number of lymphocytes was the only parameter significantly different between hospitalized and ambulatory COVID-19 patients, independently of PCR status. Conclusions: COVID-19 hemodialysis patients are frequently asymptomatic, and mortality may be lower than previously reported. Diagnosis may be retrospective, based on seroconversion, as PCR may be negative. This information should guide preventive and patient isolation strategies.
has issue date	2020-07-16(xsd:dateTime)
bibo:doi	10.3390/jcm9072264
bibo:pmid	32708750
has license	cc-by
sha1sum (hex)	8e9fa997b48c69b2649d9264d3f46eb8d8824947
schema:url	https://doi.org/10.3390/jcm9072264
resource representing a document's title	The Spectrum of Clinical and Serological Features of COVID-19 in Urban Hemodialysis Patients
has PubMed Central identifier	PMC7408812
has PubMed identifier	32708750
schema:publication	J Clin Med
resource representing a document's body	covid:8e9fa997b48c69b2649d9264d3f46eb8d8824947#body_text
is schema:about of	named entity 'COVID-19' named entity 'Clinical' named entity 'Clinical Medicine' named entity 'Hemodialysis' named entity 'COVID' »more»

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