About: Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma

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About: Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma
Creator	Miller, Richard Chrisp, Clarence Ruger, Jennifer Chalmers, Kathy Gorgas, Gayle Luciano, Ann Peterson, Joyce Turke, Paul Vancise, Simi
Source	PMC
abstract	We have assessed several age-sensitive indicators of immune status in young (i.e., 6 to 11-month-old) mice of a genetically heterogeneous population to see if these varied in parallel and to determine if one or more of the status indices predicted life span or cancer incidence. We report that the number of memory (i.e., CD44(hi)) T cells within the CD8 subset is correlated with number of memory cells in the CD4 population, and inversely correlated with the number of naive (i.e., CD45RB(hi)) CD4 cells at both 6 and 11 months of age, suggesting that the conversion of naive to memory cells may occur at similar rates in both T cell subsets. Mice that ranked high in the proportion of memory T cells (within the CD4 and CD8 pools) at 6 months of age tended to retain their ranking at 11 months, suggesting that the pace or extent of memory cell formation may be a consistent trait that distinguishes mice at least within a genetically heterogeneous population. Mice that at 6 months of age exhibited high levels ofCD4 or CD8 memory T cells, low levels of naive CD4 cells, or low levels of T cells able to proliferate in response to con a and 1l-2 were found to be significantly more likely than their littermates to die within the first 18 months of life. Cases offollicular cell lymphoma, lymphocytic and lymphoblastic lymphoma, and hepatic hemangiosarcoma were seen within the group of mice dying at early ages. Since each of the prognostic immune indices is characteristically seen in aged mice, we suggest that relatively precocious aging of the immune system may predispose a mouse to early death, particularly from lymphoma
has issue date	1994-11-01(xsd:dateTime)
bibo:doi	10.1093/geronj/49.6.b255
bibo:pmid	7525689
has license	no-cc
sha1sum (hex)	8e018ed843de3f3b45398269f60a85aa545f9dde
schema:url	https://doi.org/10.1093/geronj/49.6.b255
resource representing a document's title	Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma
has PubMed Central identifier	PMC7110387
has PubMed identifier	7525689
schema:publication	J Gerontol
resource representing a document's body	covid:8e018ed843de3f3b45398269f60a85aa545f9dde#body_text
is schema:about of	named entity 'memory T cells' named entity 'life' named entity 'prognostic' named entity 'cells' named entity 'levels' named entity 'naive' named entity 'CD44' named entity 'pace' named entity 'levels' named entity 'OCCUR' named entity 'PROPORTION' named entity 'STATUS' named entity 'MEMORY CELLS' named entity 'MEMORY CELL' named entity 'POPULATION' named entity 'CD4 CELLS' named entity 'HETEROGENEOUS' named entity 'FOUND' named entity 'MEMORY' named entity 'SEEN' named entity 'RETAIN' named entity 'MAY BE A' named entity 'LYMPHOCYTIC' covid:arg/8e018ed843de3f3b45398269f60a85aa545f9dde named entity 'consistent' named entity 'cell' named entity 'age' named entity 'memory' named entity 'high' named entity 'incidence' named entity 'CD8 memory T cells' named entity 'proliferate' named entity 'memory cells' named entity 'response' named entity 'hepatic' named entity 'CD8 memory T cells' named entity 'CD4 cells' named entity 'CD8' named entity 'immune status' named entity 'hemangiosarcoma' named entity 'high levels' named entity 'memory T cells' named entity 'CD45RB' named entity 'Mice' named entity 'Covary' named entity 'Early Death' named entity 'Lymphoma' named entity 'Genetically Heterogeneous' named entity 'CD4' named entity 'lymphoma' named entity 'control population' named entity 'naive T cells' named entity 'lymphoma' named entity 'long-lived' named entity 'CD8' named entity 'paraformaldehyde' named entity 'tumor' named entity 'biomarker' named entity 'thymus' named entity 'tumor' named entity 'CD4' named entity 'naive T cells' named entity 'correlation' named entity 'CD4 cells' named entity 'phenotypic' named entity 'solid tumors' named entity 'anti-viral' named entity 'IL-2' named entity 'CD44' named entity 'assay' named entity 'Ceredig' named entity 'CD45RB' named entity 'San Jose'

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