About: Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
Creator	Hilgenfeld, Rolf Lei, Jian Kusov, Yuri
Source	Elsevier; Medline; PMC
abstract	Abstract The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of some domains. However, eight domains of Nsp3 exist in all known CoVs: the ubiquitin-like domain 1 (Ubl1), the Glu-rich acidic domain (also called “hypervariable region”), a macrodomain (also named “X domain”), the ubiquitin-like domain 2 (Ubl2), the papain-like protease 2 (PL2pro), the Nsp3 ectodomain (3Ecto, also called “zinc-finger domain”), as well as the domains Y1 and CoV-Y of unknown functions. In addition, the two transmembrane regions, TM1 and TM2, exist in all CoVs. The three-dimensional structures of domains in the N-terminal two thirds of Nsp3 have been investigated by X-ray crystallography and/or nuclear magnetic resonance (NMR) spectroscopy since the outbreaks of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2003 as well as Middle-East Respiratory Syndrome coronavirus (MERS-CoV) in 2012. In this review, the structures and functions of these domains of Nsp3 are discussed in depth.
has issue date	2018-01-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2017.11.001
bibo:pmid	29128390
has license	els-covid
sha1sum (hex)	8df5060637cad60d903a4c41eb7a3f13b96ad35c
schema:url	https://doi.org/10.1016/j.antiviral.2017.11.001
resource representing a document's title	Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
has PubMed Central identifier	PMC7113668
has PubMed identifier	29128390
schema:publication	Antiviral Research
resource representing a document's body	covid:8df5060637cad60d903a4c41eb7a3f13b96ad35c#body_text
is schema:about of	named entity 'LARGE' named entity 'CORONAVIRUSES' named entity 'FUNCTIONS' named entity 'NSP3' named entity 'STRUCTURES' named entity 'MULTI-DOMAIN PROTEIN' named entity 'functions' named entity 'p53' named entity 'atom' named entity 'zinc-finger' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'active-site' named entity 'TNF-α' named entity 'motif' named entity 'transmembrane regions' named entity 'atom' named entity 'ubiquitin' named entity 'cysteine' named entity 'bovine coronavirus' named entity 'Trp' named entity 'ADP-ribose' named entity 'IκBα' named entity 'coronavirus' named entity 'amides' named entity 'ADPr' named entity 'MKRN3' named entity 'HCoV NL63' named entity 'SARS-CoV' named entity 'Békés' named entity 'ISG15' named entity 'protease' named entity 'Hilgenfeld' named entity 'Togaviridae' named entity 'Gln' named entity 'protein structure prediction' named entity 'titration' named entity 'SARS-CoV' named entity 'ssRNA' named entity 'Hepeviridae' named entity 'Trp' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'wild-type' named entity 'SARS-CoV' named entity 'catalytic triad' named entity 'SARS-CoV' named entity 'interact' named entity 'proteases' named entity 'Y2H' named entity 'SARS-CoV' named entity 'adenine' named entity 'Y2H' named entity 'Nsp2' named entity 'Békés' named entity 'innate immune response' named entity 'SARS-CoV' named entity 'coronavirus' named entity 'bacteria' named entity 'Nsp3' named entity 'PARP10' named entity 'NF-κB' named entity 'deltacoronaviruses' named entity 'binding sites' named entity 'alkylated' named entity 'Z-score' named entity 'papain' named entity 'signal transduction' named entity 'positively selected' named entity 'viral proteins' named entity 'cleavage' named entity 'Nsp3' named entity 'Nsp3' named entity 'ISG15' named entity 'genus' named entity 'viral genome' named entity 'Gly' named entity 'transmembrane regions'

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