About: 2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China

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About: 2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China
Creator	Shi, Ming Liu, Lei Diao, Bo Liang, Wei Shen, Bo Bu, Wenduo Cheng, Huiling Ding, Guohua Lv, Xifeng Ma, Yiqiong Wang, Huiming Zhang, Sihao Zhu, Jili
source	MedRxiv
abstract	The outbreak of COVID-19 originated in Wuhan has become a global epidemic of contagious diseases, which poses a serious threat to human life and health, especially for those with underlined diseases. However, Impacts of COVID-19 epidemic on HD center and HD patients are still unknown. In this report, we reviewed the whole course of the epidemic emerged in the HD center of Renmin Hospital, Wuhan University from January 14, 2020, the day the first case was confirmed, to February 17, 2020, the day the epidemic extinction. There are totally 37 cases among 230 HD patients and 4 cases among 33 staff being diagnosed with COVID-19. The epidemiology, clinical presentation and immune profile of dialysis patients contracted COVID-19 were further studied. We found that the two key measures we took in response to the epidemic, one was upgrading level of prevention and protection on January 21 and the other one starting universal screening, isolating, and distributing the infected cases on February 4, were effective in the epidemic control. No new COVID-19 case had been diagnosed since February 13. During the epidemic, 7 HD patients died, including 6 with COVID-19 and 1 without COVID-19. The presumed causes of death were not directly related to pneumonia, but due to cardiovascular and cerebrovascular diseases, hyperkalemia, etc. Most of the leukocytes in the peripheral blood of the HD patients infected with COVID-19 decreased, and the CT images of the chest mostly showed the ground glass like changes on the right side. The symptoms of most of the patients were mild, and there were no cases admitted to ICU. The frequency of lymphocytes in PBMCs and the serum level of inflammatory cytokines were assessed in HD patients contracted COVID-19 or not, non-HD COVID-19 patients, as well as healthy volunteers. The results showed that lymphocytes of T cell, Th cells, killer T cells, as well as NK cells in PBMCs of HD patients decreased significantly than other groups. HD patients with COVID-19 also displayed remarkable lower serum level of inflammatory cytokines than other COVID-19 patients. Our study indicates that HD patients are the highly susceptible population and HD centers are high risk area in the outbreak of COVID-19 epidemic. Measures of prevention, protection, screening, isolation, and distribution are essential in the epidemic management and should be taken in the early stage. HD Patients with COVID-19 are mostly clinical mild and unlikely progress to severe pneumonia due to the impaired cellular immune function and incapability of mounting cytokines storm. More attention should be paid to prevent cardiovascular events, which may be the collateral impacts of COVID-19 epidemic on HD patients.
has issue date	2020-02-25(xsd:dateTime)
bibo:doi	10.1101/2020.02.24.20027201
has license	medrxiv
sha1sum (hex)	8dbfb1122839fd2802805136525b502f9dc74d28
schema:url	https://doi.org/10.1101/2020.02.24.20027201
resource representing a document's title	2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China
resource representing a document's body	covid:8dbfb1122839fd2802805136525b502f9dc74d28#body_text
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