About: Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferrets

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About: Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferrets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferrets
Creator	Czub, Markus Cao, Jingxin Czub, Stefanie He, Runtao Weingartl, Hana
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) remains a threat to cause epidemics as evidenced by recent sporadic cases in China. In this communication, we evaluated the efficacy and safety of two SARS vaccine candidates based on the recombinant modified vaccinia Ankara (MVA) expressing SARS-CoV spike or nucleocapsid proteins in ferrets. No clinical signs were observed in all the ferrets challenged with SARS-CoV. On the other hand, vaccination did not prevent SARS-CoV infection in ferrets. In contrast, immunized ferrets (particularly those immunized with rMVA-spike) exhibited significantly stronger inflammatory responses and focal necrosis in liver tissue after SARS-CoV challenge than control animals. Thus, our data suggest that enhanced hepatitis is linked to vaccination with rMVA expressing SARS-CoV antigens.
has issue date	2005-03-18(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2005.01.033
bibo:pmid	15755610
has license	els-covid
sha1sum (hex)	8daa5f7a868f836dabd5f9ab0d5b766c22dea2e9
schema:url	https://doi.org/10.1016/j.vaccine.2005.01.033
resource representing a document's title	Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferrets
has PubMed Central identifier	PMC7115540
has PubMed identifier	15755610
schema:publication	Vaccine
resource representing a document's body	covid:8daa5f7a868f836dabd5f9ab0d5b766c22dea2e9#body_text
is schema:about of	named entity 'SARS-CoV' named entity 'MVA' named entity 'ferrets' named entity 'China' named entity 'ferrets' named entity 'VACCINATION' named entity 'INFLAMMATORY RESPONSES' named entity 'CAUSED BY' named entity 'BASED' named entity 'HAND' named entity 'COMMUNICATION' named entity 'RECENT' named entity 'ENHANCED' named entity 'SPIKE' named entity 'NEWLY' named entity 'OBSERVED' named entity 'HEPATITIS' named entity 'VACCINIA' named entity 'FOCAL NECROSIS' named entity 'CHALLENGE' named entity 'THREAT' named entity 'NUCLEOCAPSID PROTEINS' named entity 'SUGGEST' named entity 'CONTRAST' named entity 'DID' named entity 'CAUSE' named entity 'SARS VACCINE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'IMMUNIZED' named entity 'MODIFIED' named entity 'RECOMBINANT' named entity 'SARS VACCINE' named entity 'PREVENT' named entity 'OUR' named entity 'ANKARA' named entity 'EPIDEMICS' named entity 'LIVER TISSUE' named entity 'SAFETY' named entity 'EVALUATED' named entity 'NO CLINICAL SIGNS' named entity 'CORONAVIRUS' named entity 'BASED' named entity 'VACCINIA VIRUS ANKARA' named entity 'FERRETS' named entity 'FERRETS' named entity 'ANIMALS' named entity 'DATA' named entity 'ANTIGENS' named entity 'RECOMBINANT' named entity 'CONTROL' named entity 'SARS-COV' named entity 'CHINA' named entity 'EFFICACY' named entity 'MODIFIED' named entity 'EVALUATION' named entity 'CROWN' named entity 'IDENTIFIED' covid:arg/8daa5f7a868f836dabd5f9ab0d5b766c22dea2e9 named entity 'efficacy' named entity 'inflammatory responses' named entity 'vaccination' named entity 'nucleocapsid' named entity 'Crown' named entity 'infection' named entity 'linked' named entity 'SARS-CoV' named entity 'infection' named entity 'China' named entity 'nucleocapsid proteins' named entity 'SARS' named entity 'SARS-CoV' named entity 'inflammatory responses' named entity 'vaccination' named entity 'liver tissue' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'modified vaccinia virus Ankara'

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