About: Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review

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About: Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review
Creator	Aiello, Francesco Cesareo, Massimo Gallo, Gabriele Giannini, Clarissa Ji-Peng, • Li, Olivia Mancino, Raffaele Nucci, Carlo
Source	Medline; PMC
abstract	Coronavirus disease 19 (COVID-19) has been described to potentially be complicated by ocular involvement. However, scant information is available regarding severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and ocular structures tropism. We conducted a systematic review of articles referenced in PubMed, Cochrane Library, Web of Science and Chinese Clinical Trial Register (ChiCTR) from December 20, 2019 to April 6, 2020, providing information on the presence of SARS-CoV-2 in cornea, conjunctiva, lacrimal sac, and tears. We excluded ongoing clinical studies as for unobtainable conclusive results. Of 2422 articles, 11 met the inclusion criteria for analysis and were included in the study. None of the studies were multinational. Among the 11 selected papers there were three original articles, one review, four letters, two editorials, and one correspondence letter. Globally, 252 SARS-CoV-2 infected patients were included in our review. The prevalence of ocular conjunctivitis complicating the course of COVID-19 was demonstrated to be as high as 32% in one study only. Globally, three patients had conjunctivitis with a positive tear-PCR, 8 patients had positive tear-PCR in the absence of conjunctivitis, and 14 had conjunctivitis with negative tear-PCR. The majority of the available data regarding SARS-CoV-2 colonization of ocular and periocular tissues and secretions have to be considered controversial. However, it cannot be excluded that SARS-CoV-2 could both infect the eye and the surrounding structures. SARS-CoV-2 may use ocular structure as an additional transmission route, as demonstrated by the COVID-19 patients’ conjunctival secretion and tears positivity to reverse transcriptase-PCR SARS-CoV-2-RNA assay.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1038/s41433-020-0926-9
bibo:pmid	32424327
has license	no-cc
sha1sum (hex)	8d9a499e9ccd6124789e654462d7be7c683ee73a
schema:url	https://doi.org/10.1038/s41433-020-0926-9
resource representing a document's title	Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review
has PubMed Central identifier	PMC7232062
has PubMed identifier	32424327
schema:publication	Eye (Lond)
resource representing a document's body	covid:8d9a499e9ccd6124789e654462d7be7c683ee73a#body_text
is schema:about of	named entity 'Chinese' named entity 'COVID-19' named entity 'However' named entity 'severe' named entity 'tears' named entity 'conducted' named entity 'positive' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Coronavirus disease 2019' named entity 'COMPLICATING' named entity 'ARTICLES' named entity 'STUDIES' named entity 'OCULAR' named entity 'TEAR' named entity 'TRANSMISSION' named entity 'INCLUDED' named entity 'CHINESE' named entity 'CONCLUSIVE' named entity 'AVAILABLE' named entity 'DESCRIBED' named entity 'CONJUNCTIVITIS' named entity 'CLINICAL TRIAL' named entity 'INFECTED' named entity 'TROPISM' named entity 'COLONIZATION' named entity 'SURROUNDING' named entity 'COVID-19' named entity '2019' named entity 'correspondence' named entity 'positive' named entity 'negative' named entity 'SARS-CoV-2' named entity 'disease' named entity 'infect' named entity 'Science' named entity 'December 20' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'patients' named entity 'conjunctiva' named entity 'conjunctivitis' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'lacrimal sac' named entity 'systematic review' named entity 'PCR' named entity 'PCR' named entity 'Cochrane Library' named entity 'severe acute respiratory syndrome' named entity 'Coronavirus disease' named entity 'conjunctivitis' named entity 'PubMed' named entity 'conjunctivitis' named entity 'cornea' named entity 'PCR' named entity 'RNA' named entity 'patients' named entity 'multinational' named entity 'PCR' named entity 'RNA' named entity 'SARS-CoV' named entity 'clinical studies' named entity 'SARS-CoV' named entity 'conjunctival' named entity 'SARS-CoV-2' named entity 'RAAS' named entity 'ACE2 receptor' named entity 'SARS-CoV-2' named entity 'fever' named entity 'infection' named entity 'SARS-CoV-2' named entity 'Clinical Trial' named entity 'SARS-CoV2'

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