About: Molecular Regulation of NK Cell Maturation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Regulation of NK Cell Maturation
Creator	Wang, X Bi, J
Source	Medline; PMC
abstract	Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against tumors and infections. To reach their optimal functional status, NK cells must undergo a process of maturation from immature to mature NK cells. Genetically modified mice, as well as in vivo and in vitro NK cell differentiation assays, have begun to reveal the landscape of the regulatory network involved in NK cell maturation, in which a balance of cytokine signaling pathways leads to an optimal coordination of transcription factor activity. An increased understanding of NK cell maturation will greatly promote the development and application of NK cell-based clinical therapy. Thus, in this review, we summarize the dynamics of NK cell maturation, describe recently identified factors involved in the regulation of the NK cell maturation process, including cytokines and transcription factors, and discuss the importance of NK cell maturation in health and disease.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01945
bibo:pmid	32849653
has license	cc-by
sha1sum (hex)	8d6f79f8a6188f19b7afbbb736f2cce2a87f1ed9
schema:url	https://doi.org/10.3389/fimmu.2020.01945
resource representing a document's title	Molecular Regulation of NK Cell Maturation
has PubMed Central identifier	PMC7431948
has PubMed identifier	32849653
schema:publication	Front Immunol
resource representing a document's body	covid:8d6f79f8a6188f19b7afbbb736f2cce2a87f1ed9#body_text
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