About: IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism

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About: IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism
Creator	Hao, Jianlei Qi, Xiaofei Sun, Yuehong Wang, Puyue Wu, Zhenzhou Yao, Zhi Yin, Zhinan Zhao, Huiyuan Zhao, Liqing Zhao, Yapu Zhou, Xinglong Flavell, Richard Weaver, Casey Kaech, Susan
Source	Medline; PMC
abstract	CD8(+) T cells play an important role in immune regulation and effective immune responses against tumor cells, viral infection, and intracellular pathogens. In this report, using tiger or 10BiT mice, we defined a population of IL‐10‐producing CD8(+) T cells that were induced by IL‐4. These IL‐10(+)CD8(+) T cells possessed a strong inhibitory effect on the CD4(+) T cell proliferation in an IL‐10‐dependent and cell contact‐dependent fashion. In comparison with IL‐10(−)CD8(+) T cells, IL‐10(+)CD8(+) T cells expressed an array of Th2‐like cytokines (IL‐4, IL‐5), perforin, and granzymes, as well as the cell cycle regulatory protein Cdkn2a. Interestingly, knockdown of cdkn2a using siRNA reduced IL‐4‐induced IL‐10 production significantly. Furthermore, CD8(+) T cells from Cdkn2a(−/−) mice produced a significantly lower amount of IL‐10, and the effect was limited to CD8(+) T cells but not observed in CD4(+) T cells and APCs. Finally, IL‐10(+)CD8(+) T cells played a protective role in the TNBS‐induced murine colitis model, indicating a critical role of this population of CD8(+) T cells in regulatory immune responses. Taken together, we have defined a population of IL‐10‐producing CD8(+) Tregs induced by IL‐4 and mediated by Cdkn2a.
has issue date	2013-06-14(xsd:dateTime)
bibo:doi	10.1189/jlb.0213064
bibo:pmid	23772040
has license	green-oa
sha1sum (hex)	8d2a523d5c625a947a59c53634a9657bd203abe9
schema:url	https://doi.org/10.1189/jlb.0213064
resource representing a document's title	IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism
has PubMed Central identifier	PMC6607996
has PubMed identifier	23772040
schema:publication	Journal of Leukocyte Biology
resource representing a document's body	covid:8d2a523d5c625a947a59c53634a9657bd203abe9#body_text
is schema:about of	named entity 'T cell' named entity 'granzymes' named entity 'array' named entity 'induced' named entity 'T cells' named entity 'Cdkn2a' named entity 'IL-10' named entity 'perforin' named entity 'CD8' named entity 'T CELL PROLIFERATION' named entity 'REGULATORY' named entity 'EFFECTIVE' named entity 'CRITICAL' named entity 'CELL CYCLE REGULATORY PROTEIN' named entity 'IL-4' named entity 'IL-5' named entity 'IMMUNE' named entity 'INHIBITORY EFFECT' named entity 'POSSESSED' named entity 'T CELLS' named entity 'CD8' named entity 'CD8' named entity 'IL-10' named entity 'immune responses' named entity 'production' named entity 'APCs' named entity 'produced' named entity 'cell cycle' named entity 'CD8' named entity 'IL-10' named entity 'Cdkn2a' named entity 'Cdkn2a' named entity 'CD8' named entity 'mice' named entity 'critical role' named entity 'IL-10' named entity 'IL-10' named entity 'murine' named entity 'IL-10' named entity 'immune responses' named entity 'CD4' named entity 'IL-4' named entity 'tumor cells' named entity 'CD8' named entity 'CD4' named entity 'IL-10' named entity 'CD44' named entity 'London' named entity 'expression levels' named entity 'CD8' named entity 'transgenic mice' named entity 'cytokine' named entity 'CD28' named entity 'BD Biosciences' named entity 'CD8' named entity 'Thy1.1' named entity 'CD8' named entity 'GFP' named entity 'antibody staining' named entity 'CD69' named entity 'CD8' named entity 'IL-4' named entity 'Th2' named entity 'tumor' named entity 'specific role' named entity 'mice' named entity 'IL-4' named entity 'IFN'

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