About: Clinical effect and safety of continuous renal replacement therapy in the treatment of neonatal sepsis-related acute kidney injury

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About: Clinical effect and safety of continuous renal replacement therapy in the treatment of neonatal sepsis-related acute kidney injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical effect and safety of continuous renal replacement therapy in the treatment of neonatal sepsis-related acute kidney injury
Creator	Cai, Cheng Gong, Xiaohui Hong, Wenchao Qiu, Gang Shen, Yunlin
Source	PMC
abstract	BACKGROUND: Sepsis is the leading cause of acute kidney injury (AKI) in the neonatal intensive care unit (NICU). The aim of the study is to explore the efficacy and security of continuous renal replacement therapy (CRRT) in the treatment of neonatal sepsis-related AKI. METHOD: Totally12 sepsis-related AKI neonates treated with CRRT were hospitalized in the NICU of Shanghai Children’s Hospital between November 2012 and November 2019, and the clinical data of these 12 cases were retrospectively analyzed. Renal function, acid-base balance, electrolytes, blood pressure and hemodynamics indexes were recorded before CRRT initiation, 12/24/48 h after CRRT initiation and at the end of CRRT respectively. The efficacy of CRRT was evaluated and the clinical outcome was observed in these 12 sepsis-related AKI neonates. Repeated measurement analysis of variance was used for statistical analysis of the data. RESULT: (1) Continuous veno-venous hemodialysis filtration (CVVHDF) was used in 12 cases of sepsis-related AKI neonates. There were 6 cases with oliguria, 3 cases with fluid overload (FO), 3 cases with septic shock. The duration of CRRT was 49 ~ 110 h, average (76.2 ± 23.5) h. (2) The blood pressure (BP) of 12 sepsis -related AKI neonates could reach the normal level (40–60 mmHg) 12 h after CRRT initiation, and the normal BP level could be maintained during the CRRT treatment. After 12 h CRRT, the blood pH value increased to the normal range (7.35 ~ 7.45). After 12 h CRRT treatment, the oxygenation index of 12sepsis-related AKI neonates could reach 200 mmHg. After 24 h CRRT treatment, it could rise to more than 300 mmHg. Serum potassium, serum urea nitrogen and serum creatinine levels decreased significantly 12 h after CRRT initiation, and reached the normal range 24 h after CRRT initiation. The urine volume significantly increased 24 h after CRRT initiation. (3) Venous catheterization was performed successfully in all sepsis-related AKI neonates. We observed 2 cases of thrombocytopenia, 1 case of obstruction and 1 case of hypotension in the course of CRRT. There were no complications such as hypothermia, hemorrhage, thrombosis and infection.11 neonates were cured and discharged. One neonate was treated with CRRT and passed through the oliguria stage of AKI, but died after the parents gave up the treatment. CONCLUSIONS: It is safe and effective to treat neonatal sepsis-related AKI with CRRT, which should be an effective measure for the treatment of sepsis-related AKI neonates.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1186/s12882-020-01945-z
has license	cc-by
sha1sum (hex)	8cf653e22b71a5fab6aebf1b1ef747ea9d5da3a2
schema:url	https://doi.org/10.1186/s12882-020-01945-z
resource representing a document's title	Clinical effect and safety of continuous renal replacement therapy in the treatment of neonatal sepsis-related acute kidney injury
has PubMed Central identifier	PMC7368639
schema:publication	BMC Nephrol
resource representing a document's body	covid:8cf653e22b71a5fab6aebf1b1ef747ea9d5da3a2#body_text
is schema:about of	named entity 'CONTINUOUS RENAL REPLACEMENT THERAPY' named entity 'AIM' named entity 'AKI' named entity 'neonatal intensive care unit (NICU)' named entity 'acute kidney injury' named entity 'safety' named entity 'continuous renal replacement therapy' named entity 'AKI' named entity 'AKI' named entity 'stage 1' named entity 'critically ill patients' named entity 'risk factor' named entity 'CRRT' named entity 'NICU' named entity 'dialysate' named entity 'neonates' named entity 'sepsis' named entity 'respiratory distress' named entity 'hemodynamic' named entity 'water balance' named entity 'CRRT' named entity 'blood circulation' named entity 'renal function' named entity 'IRB' named entity 'clinical practice guidelines' named entity 'magnesium sulfate' named entity 'neonates' named entity 'AKI' named entity 'Prognosis' named entity 'neonates' named entity 'Escherichia coli' named entity 'sepsis' named entity 'CRRT' named entity 'AKI' named entity 'metabolism' named entity 'Serum' named entity 'gestational age' named entity 'anticoagulant' named entity 'CRRT' named entity 'calcium chloride' named entity 'prognosis' named entity 'neonates' named entity 'blood gas analysis' named entity 'sepsis' named entity 'neonates' named entity 'CRRT' named entity 'acid-base balance' named entity 'femoral vein' named entity 'proximal' named entity 'septic shock' named entity 'AKI' named entity 'catheterization' named entity 'GBS' named entity 'blood coagulation' named entity 'urine' named entity 'alkali' named entity 'arterial partial pressure of oxygen' named entity 'sepsis' named entity '2.0' named entity 'low birth weight' named entity 'infection' named entity 'oliguria' named entity 'CRRT' named entity 'AKI' named entity 'sepsis' named entity 'CRRT' named entity 'AKI' named entity 'AKI' named entity 'CRRT' named entity 'multiple organ dysfunction' named entity 'solute' named entity 'thrombosis' named entity '1, 2' named entity 'AKI' named entity 'CRRT' named entity 'blood culture' named entity 'dialysate' named entity 'CRRT' named entity 'Hypotension'

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