About: Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance

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About: Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance
Creator	Hu, Yi Zhou, Hong Zhao, Yang Lu, Yang Li, Ruiyun Tan, Weijun Yuan, Mingli Wang, Yihua Wu, Xiaojun Ding, Xuhong Nie, Hanxiang Ewing, Rob Liu, Hailing Liu, Xiaofan Zhou, Yilu Zou, Jinjing
Source	Medline; PMC
abstract	COVID-19 is “public enemy number one” and has placed an enormous burden on health authorities across the world. Given the wide clinical spectrum of COVID-19, understanding the factors that can predict disease severity will be essential since this will help frontline clinical staff to stratify patients with increased confidence. To investigate the diagnostic value of the temporal radiographic changes, and the relationship to disease severity and viral clearance in COVID-19 patients. In this retrospective cohort study, we included 99 patients admitted to the Renmin Hospital of Wuhan University, with laboratory confirmed moderate or severe COVID-19. Temporal radiographic changes and viral clearance were explored using appropriate statistical methods. Radiographic features from HRCT scans included ground-glass opacity, consolidation, air bronchogram, nodular opacities and pleural effusion. The HRCT scores (peak) during disease course in COVID-19 patients with severe pneumonia (median: 24.5) were higher compared to those with pneumonia (median: 10) (p = 3.56 × 10 (−12)), with more frequency of consolidation (p = 0.025) and air bronchogram (p = 7.50 × 10(−6)). The median values of days when the peak HRCT scores were reached in pneumonia or severe pneumonia patients were 12 vs. 14, respectively (p = 0.048). Log-rank test and Spearman’s Rank-Order correlation suggested temporal radiographic changes as a valuable predictor for viral clearance. In addition, follow up CT scans from 11 pneumonia patients showed full recovery. Given the values of HRCT scores for both disease severity and viral clearance, a standardised HRCT score system for COVID-19 is highly demanded.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1038/s41598-020-66895-w
bibo:pmid	32581324
has license	cc-by
sha1sum (hex)	8cddb676c8b2e2ef79d86da9fb966f78fa152f45
schema:url	https://doi.org/10.1038/s41598-020-66895-w
resource representing a document's title	Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance
has PubMed Central identifier	PMC7314788
has PubMed identifier	32581324
schema:publication	Sci Rep
resource representing a document's body	covid:8cddb676c8b2e2ef79d86da9fb966f78fa152f45#body_text
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