About: Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection

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About: Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection
Creator	Lin, Chun-Ching Lin, Liang-Tzung Hung, Ting-Chun Jassey, Alagie Lin, Chien-Ju Liu, Ching-Hsuan Yen, Ming-Hong
Source	PMC
abstract	Hepatitis C Virus (HCV) remains an important public health threat with approximately 170 million carriers worldwide who are at risk of developing hepatitis C-associated end-stage liver diseases. Despite improvement of HCV treatment using the novel direct-acting antivirals (DAAs) targeting viral replication, there is a lack of prophylactic measures for protection against HCV infection. Identifying novel antivirals such as those that target viral entry could help broaden the therapeutic arsenal against HCV. Herein, we investigated the anti-HCV activity of the methanolic extract from Rhizoma coptidis (RC), a widely used traditional Chinese medicine documented by the WHO and experimentally reported to possess several pharmacological functions including antiviral effects. Using the cell culture-derived HCV system, we demonstrated that RC dose-dependently inhibited HCV infection of Huh-7.5 cells at non-cytotoxic concentrations. In particular, RC blocked HCV attachment and entry/fusion into the host cells without exerting any significant effect on the cell-free viral particles or modulating key host cell entry factors to HCV. Moreover, RC robustly suppressed HCV pseudoparticles infection of Huh-7.5 cells and impeded infection by several HCV genotypes. Collectively, our results identified RC as a potent antagonist to HCV entry with potential pan-genotypic properties, which deserves further evaluation for use as an anti-HCV agent.
has issue date	2018-11-27(xsd:dateTime)
bibo:doi	10.3390/v10120669
bibo:pmid	30486350
has license	cc-by
sha1sum (hex)	8cd645b337ac36abbd467302eb73b4ae086e60ac
schema:url	https://doi.org/10.3390/v10120669
resource representing a document's title	Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection
has PubMed Central identifier	PMC6315547
has PubMed identifier	30486350
schema:publication	Viruses
resource representing a document's body	covid:8cd645b337ac36abbd467302eb73b4ae086e60ac#body_text
is schema:about of	named entity 'EXTRACT' named entity 'pharmacological' named entity 'viral entry' named entity 'STEPS' named entity 'DOSE' named entity 'HUH-7.5' named entity 'NON-' named entity 'VIRAL ENTRY' named entity 'TARGET' named entity 'RHIZOMA COPTIDIS' named entity 'DERIVED' named entity 'REPORTED' named entity 'USE' named entity 'EXERTING' named entity 'INFECTION' named entity 'PROPHYLACTIC' covid:arg/8cd645b337ac36abbd467302eb73b4ae086e60ac named entity 'POSSESS' named entity 'DEMONSTRATED' named entity 'THERAPEUTIC' named entity 'VIRAL PARTICLES' named entity 'IMPORTANT' named entity 'PAN' named entity 'INVESTIGATED' named entity 'VIRAL ENTRY' named entity 'SIGNIFICANT' named entity 'FUNCTIONS' named entity 'RHIZOMA COPTIDIS' named entity 'EFFECTS' named entity 'KEY' named entity 'SYSTEM' named entity 'HEPATITIS C VIRUS INFECTION' named entity 'MODULATING' named entity 'DOCUMENTED' named entity 'END-STAGE' named entity 'TRADITIONAL CHINESE MEDICINE' named entity 'RISK OF' named entity 'HCV INFECTION' named entity 'IDENTIFYING' named entity 'ANTAGONIST' named entity 'GENOTYPIC' named entity 'HCV' named entity 'HOST CELL' named entity 'ASSOCIATED' named entity 'PROTECTION' named entity 'ACTIVITY' named entity 'AGENT' named entity 'HOST CELLS' named entity 'GENOTYPES' named entity 'HEPATITIS C VIRUS' named entity 'VIRAL REPLICATION' named entity 'USED' named entity 'ENTRY' named entity 'APPROXIMATELY' named entity 'ATTACHMENT' named entity 'ANTIVIRALS' named entity 'NOVEL' named entity 'CARRIERS' named entity 'LIVER DISEASES' named entity 'WORLDWIDE' named entity 'TREATMENT' named entity 'ANTIVIRAL' named entity 'IS A' named entity 'DEVELOPING' named entity 'FREE' named entity 'POTENTIAL' named entity 'ARSENAL' named entity 'BLOCKED' named entity 'IMPROVEMENT' named entity 'PUBLIC HEALTH' named entity 'HEPATITIS C' named entity 'THE CELL' named entity 'HELP' named entity 'MILLION' named entity 'IDENTIFIED'

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